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1. (WO2019050015) CELL AGGREGATE INCLUDING RETINAL TISSUE AND PRODUCTION METHOD THEREFOR
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Pub. No.: WO/2019/050015 International Application No.: PCT/JP2018/033299
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12N 5/079 (2010.01) ,A61K 35/30 (2015.01) ,A61L 27/38 (2006.01) ,A61L 27/40 (2006.01) ,A61P 27/02 (2006.01) ,C12N 5/0735 (2010.01) ,C12Q 1/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
079
Neural cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
30
Nerves; Brain
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
38
Animal cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
40
Composite materials, i.e. layered or containing one material dispersed in a matrix of the same or different material
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27
Drugs for disorders of the senses
02
Ophthalmic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
073
Embryonic cells or tissues; Foetal cells or tissues
0735
Embryonic stem cells; Embryonic germ cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
06
Quantitative determination
Applicants:
国立研究開発法人理化学研究所 RIKEN [JP/JP]; 埼玉県和光市広沢2番1号 2-1, Hirosawa, Wako-shi, Saitama 3510198, JP
大日本住友製薬株式会社 SUMITOMO DAINIPPON PHARMA CO., LTD. [JP/JP]; 大阪府大阪市中央区道修町2丁目6番8号 6-8, Dosho-machi 2-chome, Chuo-ku, Osaka-shi, Osaka 5418524, JP
Inventors:
高橋 政代 TAKAHASHI Masayo; JP
万代 道子 MANDAI Michiko; JP
山▲崎▼ 優 YAMASAKI Suguru; JP
Agent:
長谷川 芳樹 HASEGAWA Yoshiki; JP
清水 義憲 SHIMIZU Yoshinori; JP
Priority Data:
2017-17340408.09.2017JP
Title (EN) CELL AGGREGATE INCLUDING RETINAL TISSUE AND PRODUCTION METHOD THEREFOR
(FR) AGRÉGAT CELLULAIRE COMPRENANT DU TISSU RÉTINIEN, ET MÉTHODE DE PRODUCTION CORRESPONDANTE
(JA) 網膜組織を含む細胞凝集体及びその製造方法
Abstract:
(EN) This spherical cell aggregate according to one embodiment of the present invention comprises a core section including a neural retina, and a cover section continuously or non-continuously covering at least a portion of the surface of the core section, and is characterized in that: (1) in the neural retina, a neural retina layer including at least a visual cell layer is formed, the visual cell layer includes at least one type of cells selected from the group consisting of visual cells, visual cell precursor cells, and retina precursor cells, and cells included in the visual cell layer are continuously present in a direction tangential to the surface of the core section; (2) the cover section includes retinal pigment epithelial cells that are in contact with each other; (3) the cell aggregate does not include the crystalline lens, the vitreous body, the cornea, or blood vessels; and (4) the retinal pigment epithelial cells and the neural retina layer do not together form a continuous epithelial structure.
(FR) L'agrégat de cellules sphériques selon un mode de réalisation de la présente invention comprend une zone centrale comprenant de la rétine neurale, et une zone de couverture recouvrant de façon continue ou discontinue au moins une partie de la surface de la zone centrale, et est caractérisé en ce que : (1) dans la rétine neurale, une couche de rétine neurale comprenant au moins une couche de cellules visuelles est formée, la couche de cellules visuelles comprenant au moins un type de cellules sélectionnées dans le groupe constitué de cellules visuelles, de cellules précurseurs de cellules visuelles, et de cellules précurseurs de la rétine, les cellules comprises dans la couche de cellules visuelles étant présentes en continu dans une direction tangentielle à la surface de la zone centrale ; (2) la zone de couverture comprend des cellules de l'épithélium pigmentaire rétinien qui sont en contact les unes avec les autres ; (3) l'agrégat cellulaire ne comprend pas de cristallin, de corps vitré, de cornée ni de vaisseaux sanguins ; et (4) les cellules de l'épithélium pigmentaire rétinien et la couche de rétine neurale ne forment pas ensemble une structure épithéliale continue.
(JA) 本発明の一実施形態のスフェア状細胞凝集体は、神経網膜を含むコア部と、前記コア部の表面の少なくとも一部を連続的に又は断続的に覆う被覆部とを備える、スフェア状細胞凝集体であって、 (1)前記神経網膜において、少なくとも視細胞層を含む神経網膜層が形成されており、前記視細胞層は少なくとも視細胞、視細胞前駆細胞及び網膜前駆細胞からなる群から選択される1以上の細胞を含み、前記視細胞層に含まれる細胞が前記コア部の表面の接線方向に連続して存在しており、 (2)前記被覆部は、互いに接触する網膜色素上皮細胞を含み、 (3)前記細胞凝集体は、水晶体、硝子体、角膜及び血管を含まず、かつ (4)前記網膜色素上皮細胞は、前記神経網膜層とともに連続する上皮構造を構成していない ことを特徴とする。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)