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1. (WO2019049960) TEST METHOD FOR DEPRESSION SYMPTOMS AND SCREENING METHOD OF THERAPEUTIC AGENT THEREFOR
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Pub. No.: WO/2019/049960 International Application No.: PCT/JP2018/033121
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12Q 1/04 (2006.01) ,A61K 31/137 (2006.01) ,A61P 9/00 (2006.01) ,A61P 25/24 (2006.01) ,A61P 35/00 (2006.01) ,C12Q 1/689 (2018.01) ,G01N 33/15 (2006.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
13
Amines, e.g. amantadine
135
having aromatic rings, e.g. methadone
137
Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
[IPC code unknown for C12Q 1/689]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
15
Medicinal preparations
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
国立大学法人千葉大学 NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY [JP/JP]; 千葉県千葉市稲毛区弥生町1番33号 1-33, Yayoi-cho, Inage-ku, Chiba-shi, Chiba 2638522, JP
Inventors:
橋本 謙二 HASHIMOTO Kenji; JP
Agent:
白形 由美子 SHIRAKATA Yumiko; JP
Priority Data:
2017-17216707.09.2017JP
Title (EN) TEST METHOD FOR DEPRESSION SYMPTOMS AND SCREENING METHOD OF THERAPEUTIC AGENT THEREFOR
(FR) MÉTHODE DE TEST DE SYMPTÔMES DE LA DÉPRESSION ET MÉTHODE DE CRIBLAGE D'AGENTS THÉRAPEUTIQUES CORRESPONDANT
(JA) うつ症状の検査方法、及び治療薬のスクリーニング方法
Abstract:
(EN) By analyzing intestinal bacterial flora, the present inventors found intestinal bacteria specific to depression symptoms. Detection of these bacteria enables differential diagnosis of depression symptoms associated with neuropsychiatric disorders, cancer or circulatory disorders. Moreover, these bacteria are usable as an index in screening a drug which is efficacious against depression symptoms. The present inventors also found intestinal bacteria showing a recovery to a level comparable to a control upon dosing of (R)-ketamine. Thus, a patient highly sensitive to (R)-ketamine can be selected by analyzing the intestinal bacterial flora.
(FR) En analysant la flore bactérienne intestinale, les présents inventeurs ont découvert des bactéries intestinales spécifiques des symptômes de la dépression. La détection de ces bactéries permet le diagnostic différentiel des symptômes de la dépression associés à des troubles neuropsychiatriques, au cancer, ou à des troubles de la circulation. De plus, ces bactéries peuvent être utilisées comme indicateur dans le criblage de médicaments efficaces contre les symptômes de la dépression. Les présents inventeurs ont également découvert des bactéries intestinales présentant une récupération à un niveau comparable à un contrôle lors de l'administration de (R)-kétamine. Ainsi, un patient hautement sensible à la (R)-kétamine peut être sélectionné en analysant sa flore bactérienne intestinale.
(JA) 腸内細菌叢を解析することによって、うつ症状に特異的な腸内細菌を見出した。これらの細菌を検出することにより、精神神経疾患、がん、循環器疾患によるうつ症状を鑑別診断することができる。また、これら細菌をうつ症状に効果を有する薬剤のスクリーニングの指標として用いることができる。また、(R)-ケタミン投与によってコントロールと同程度まで改善する腸内細菌を見出した。腸内細菌叢を解析することによって、(R)-ケタミンに対して感受性の高い患者を選択することができる。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)