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1. (WO2019049956) ANTITUMOR AGENT AND ANTITUMOR EFFECT POTENTIATOR
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Pub. No.: WO/2019/049956 International Application No.: PCT/JP2018/033108
Publication Date: 14.03.2019 International Filing Date: 06.09.2018
IPC:
A61K 31/47 (2006.01) ,A61K 39/395 (2006.01) ,A61K 45/00 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 43/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43
Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
Applicants:
大鵬薬品工業株式会社 TAIHO PHARMACEUTICAL CO., LTD. [JP/JP]; 東京都千代田区神田錦町1-27 1-27, Kandanishiki-cho, Chiyoda-ku, Tokyo 1018444, JP
Inventors:
春間 智統 HARUMA Tomonori; JP
Agent:
特許業務法人栄光特許事務所 EIKOH PATENT FIRM, P.C.; 東京都港区西新橋一丁目7番13号 虎ノ門イーストビルディング10階 Toranomon East Bldg. 10F, 7-13, Nishi-Shimbashi 1-chome, Minato-ku, Tokyo 1050003, JP
Priority Data:
2017-17335208.09.2017JP
Title (EN) ANTITUMOR AGENT AND ANTITUMOR EFFECT POTENTIATOR
(FR) AGENT ANTITUMORAL ET POTENTIALISATEUR D'EFFET ANTITUMORAL
(JA) 抗腫瘍剤及び抗腫瘍効果増強剤
Abstract:
(EN) The purpose of the present invention is to provide a novel antitumor agent that exhibits a remarkably excellent antitumor effect and has few side effects. The present invention relates to an antitumor agent characterized by the concomitant administration of an acyl thiourea compound represented by general formula (I) or a salt thereof and an immune checkpoint regulator.
(FR) L'objectif de la présente invention est de fournir un nouvel agent antitumoral qui présente des propriétés antitumorales d'une excellence exceptionnelle, et ne provoque que peu d'effets indésirables. La présente invention concerne un agent antitumoral caractérisé par l'administration concomitante d'un composé acyle thiourée représenté par la formule générale (I) ou d'un sel correspondant, et d'un régulateur de point de contrôle immunitaire.
(JA) 本発明は、顕著に優れた抗腫瘍効果を示し、副作用の少ない新規な抗腫瘍剤の提供を目的とする。本発明は、一般式(I)で表されるアシルチオウレア化合物又はその塩と、免疫チェックポイント分子調節剤とを併用投与することを特徴とする抗腫瘍剤に関する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)