Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019049734) NOVEL POLY(ETHYLENE GLYCOL) DERIVATIVE AND PROTEIN-ADSORPTION INHIBITOR
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/049734 International Application No.: PCT/JP2018/031801
Publication Date: 14.03.2019 International Filing Date: 28.08.2018
IPC:
C08G 65/32 (2006.01) ,G01N 33/531 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
65
Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
02
from cyclic ethers by opening of the heterocyclic ring
32
Polymers modified by chemical after-treatment
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
531
Production of immunochemical test materials
Applicants:
日油株式会社 NOF CORPORATION [JP/JP]; 東京都渋谷区恵比寿4丁目20番3号 20-3, Ebisu 4-chome, Shibuya-ku, Tokyo 1506019, JP
Inventors:
鹿取 茜 KATORI, Akane; JP
松田 将 MATSUDA, Masaru; JP
野田 朋澄 NODA, Tomozumi; JP
佐々木 崇 SASAKI, Takashi; JP
鈴木 裕貴 SUZUKI, Hirotaka; JP
坂元 伸行 SAKAMOTO, Nobuyuki; JP
Agent:
酒井 一 SAKAI Hajime; JP
蔵合 正博 ZOGO Masahiro; JP
Priority Data:
2017-17372511.09.2017JP
Title (EN) NOVEL POLY(ETHYLENE GLYCOL) DERIVATIVE AND PROTEIN-ADSORPTION INHIBITOR
(FR) NOUVEAU DÉRIVÉ POLY(ÉTHYLÈNE GLYCOL) ET INHIBITEUR D’ADSORPTION DE PROTÉINE
(JA) 新規ポリエチレングリコール誘導体および蛋白質吸着抑制剤
Abstract:
(EN) Provided is a compound which has an extremely high protein-adsorption inhibition effect wherein the compound is effectively adsorbed onto the surface of a base, e.g., an immunoreaction vessel, to prevent non-specific adsorption of proteins, etc., and which has such excellent cleaning resistance that said effect does not change through cleaning of the base. Also provided are a protein-adsorption inhibitor including said compound, a phosphorylcholine-modified base, and a method for inhibiting protein adsorption. The compound is a phosphorylcholine-group-containing poly(ethylene glycol) derivative represented by formula (1). The method for inhibiting protein adsorption according to the present invention includes a step in which an adsorption layer of the derivative is formed on a base surface.
(FR) La présente invention concerne un composé qui présente un effet d’inhibition extrêmement élevé de l’adsorption de protéine, le composé étant efficacement adsorbé sur la surface d’une base, par exemple, d’un récipient d’immunoréaction, pour empêcher l’adsorption non spécifique des protéines, etc., et qui présente une telle résistance au nettoyage que ledit effet ne change pas à travers le nettoyage de la base. La présente invention concerne également un inhibiteur d’adsorption de protéine comprenant ledit composé, une base modifiée avec de la phosphorylcholine, et un procédé d’inhibition de l’adsorption de protéine. Le composé est un dérivé poly(éthylène glycol) contenant le groupe phosphorylcholine représenté par la formule (1). Le procédé d’inhibition de l’adsorption de protéine selon la présente invention comprend une étape dans laquelle une couche d’adsorption du dérivé est formée sur une surface de base.
(JA) 免疫反応容器等の基材表面に効果的に吸着し、蛋白質等の非特異的吸着を防止する蛋白質吸着抑制効果が極めて高く、かつ、基材の洗浄操作前後で該効果が変化しない耐洗浄性に優れた化合物を提供する。また、当該化合物を用いた蛋白質吸着抑制剤、ホスホリルコリン修飾基材、及び蛋白質吸着抑制方法を提供する。この化合物は式(1)で示されるホスホリルコリン基含有ポリエチレングリコール誘導体である。本発明の蛋白質吸着抑制方法は、基材表面に該誘導体の吸着層を形成する工程を有する。
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)