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1. (WO2019049174) SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF
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Pub. No.: WO/2019/049174 International Application No.: PCT/IN2018/050583
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C07D 239/54 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
239
Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02
not condensed with other rings
24
having three or more double bonds between ring members or between ring members and non-ring members
28
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46
Two or more oxygen, sulfur or nitrogen atoms
52
Two oxygen atoms
54
as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
Applicants:
MSN LABORATORIES PRIVATE LIMITED, R&D CENTER [IN/IN]; Plot No. 12, Phase-IV, Sy No. 119 to 140, 258, 275 to 280, IDA, Pashamylaram (Vill), Patancheru (Mdl), Sangareddy (Dist), Telangana (State) Hyderabad 502307, IN
Inventors:
SRINIVASAN, Thirumalai Rajan; IN
SAJJA, Eswaraiah; IN
GHOJALA, Venkat Reddy; IN
SAGYAM, Rajeshwar Reddy; IN
RANGINENI, Srinivasulu; IN
KOMMERA, Rajashekar; IN
BEKKAM, Markandeya; IN
Priority Data:
20174103174807.09.2017IN
20174103339120.09.2017IN
20184101242702.04.2018IN
20184101596127.04.2018IN
Title (EN) SOLID STATE FORMS OF 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)METHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE HYDROCHLORIDE AND THEIR PROCESSES FOR THE PREPARATION THEREOF
(FR) FORMES À L'ÉTAT SOLIDE DE CHLORHYDRATE DE 5-CHLORO-6-[(2-IMINOPYRROLIDIN-1-YL)MÉTHYL]PYRIMIDINE-2,4-(1H,3H)-DIONE ET PROCÉDÉS DE PRÉPARATION ASSOCIÉS
Abstract:
(EN) The present invention relates to solid state forms of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride compound of formula-1a and their processes for the preparation thereof and an improved process for the preparation of 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione hydrochloride. The present inventors also provides an amorphous polymorph of the combination drug consisting of 2'-deoxy-5-(trifluoromethyl) uridine and 5-chloro-6-[(2-iminopyrrolidin-1-yl)methyl]pyrimidine-2,4-(1H,3H)-dione monohydrochloride and its process for the preparation.
(FR) La présente invention concerne des formes à l'état solide de chlorhydrate de 5-chloro-6-[(2-iminopyrrolidin-1-yl)méthyl] pyrimidine-2,4-(1H,3H)-dione de formule 1a et leurs procédés de préparation ainsi qu'un procédé amélioré de préparation de chlorhydrate de 5-chloro-6-[(2-iminopyrrolidin-1-yl) méthyl] pyrimidine-2,4-(1H,3H)-dione. Les présents inventeurs proposent également un polymorphe amorphe du médicament combiné constitué de 2'-désoxy-5-(trifluorométhyl)uridine et de monochlorhydrate 5-chloro-6-[(2-iminopyrrolidin-1-yl)méthyl]pyrimidine-2,4-(1H,3H)-dione et son procédé de préparation.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)