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1. (WO2019049145) COMPOSITIONS AND METHODS FOR NASAL ADMINISTRATION OF DRUGS TO BRAIN AND FOR SYSTEMIC EFFECT
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Pub. No.: WO/2019/049145 International Application No.: PCT/IL2018/051004
Publication Date: 14.03.2019 International Filing Date: 06.09.2018
IPC:
A61K 9/00 (2006.01) ,A61K 47/02 (2006.01) ,A61K 47/10 (2017.01) ,A61K 47/24 (2006.01) ,A61P 23/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
02
Inorganic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
08
containing oxygen
10
Alcohols; Phenols; Salts thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
24
containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
23
Anaesthetics
Applicants:
YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. [IL/IL]; Hi-Tech Park Edmond J Safra Campus - Givat Ram P.O. Box 39135 9139002 Jerusalem, IL
Inventors:
TOUITOU, Elka; IL
NATSHEH, Hiba; IL
Agent:
PYERNIK, Moshe; IL
LAPIDOT, Ariel; IL
LEVANT, Avital; IL
SHAHAR, Chen; IL
Priority Data:
62/556,50911.09.2017US
Title (EN) COMPOSITIONS AND METHODS FOR NASAL ADMINISTRATION OF DRUGS TO BRAIN AND FOR SYSTEMIC EFFECT
(FR) COMPOSITIONS ET PROCÉDÉS POUR L'ADMINISTRATION NASALE DE MÉDICAMENTS EN DIRECTION DU CERVEAU ET EN VUE D'UN EFFET SYSTÉMIQUE
Abstract:
(EN) The invention relates to a nasally administrable composition comprising at least one active substance in magnesium- containing vesicular carrier, said carrier comprising glycol, phospholipids, water and at least one magnesium source. Methods for nasal administration of the composition, for example, for pain relief, are also provided.
(FR) L'invention concerne une composition administrable par voie nasale comprenant au moins une substance active dans un support vésiculaire contenant du magnésium, ledit support comprenant du glycol, des phospholipides, de l'eau et au moins une source de magnésium. L'invention concerne également des procédés d'administration nasale de la composition, par exemple pour le soulagement de la douleur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Licensing availability request The applicant has requested the International Bureau to indicate the availability for licensing purposes of the invention(s) claimed in this international application