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1. (WO2019048974) PROCESS FOR THE PREPARATION OF NINTEDANIB
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Pub. No.: WO/2019/048974 International Application No.: PCT/IB2018/056429
Publication Date: 14.03.2019 International Filing Date: 24.08.2018
IPC:
C07D 209/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
32
Oxygen atoms
34
in position 2
Applicants:
GLENMARK PHARMACEUTICALS LIMITED [IN/IN]; Glenmark House, HDO- Corporate Building, Wing-A, B. D. Sawant Marg, Chakala, Andheri (East) Mumbai Maharashtra 400099, IN
Inventors:
NAIK, Samir; IN
SRIVASTAVA, Sachin; IN
PATIL, Pramod; IN
PATIL, Premchand Bansilal; IN
BHIRUD, Shekhar Bhaskar; IN
Priority Data:
20172103150906.09.2017IN
Title (EN) PROCESS FOR THE PREPARATION OF NINTEDANIB
(FR) PROCÉDÉ DE PRÉPARATION DE NINTÉDANIB
Abstract:
(EN) The present invention relates to a process for the preparation of nintedanib or salt thereof. The process comprising reacting compound of formula VI with acetic anhydride and triethyl ortho benzoate to obtain a compound of formula V; further reacting the compound of formula V with the compound of formula IV to obtain nintedanib the compound of formula I. The present invention also relates to a process to obtain crystalline compound of formula V.
(FR) La présente invention concerne un procédé de préparation de nintédanib et de son sel. Le procédé selon l'invention consiste à faire réagir un composé de formule VI avec de l'anhydride acétique et du benzoate ortho-triéthyle pour obtenir un composé de formule V ; faire réagir ensuite le composé de formule V avec un composé de formule IV pour obtenir du nintédanib composé de formule I. La présente invention concerne également un procédé pour obtenir un composé cristallin de formule V.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)