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1. (WO2019048923) TRANS-ISOMERIC HETEROCYCLIC COMPOUNDS AND PREPARATION THEREOF
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Pub. No.: WO/2019/048923 International Application No.: PCT/IB2018/001044
Publication Date: 14.03.2019 International Filing Date: 10.08.2018
IPC:
C07D 211/36 (2006.01) ,C07D 211/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06
having no double bonds between ring members or between ring members and non-ring members
36
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
211
Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
02
Preparation by ring-closure or hydrogenation
Applicants:
HSU, Ming-chu; TW
TAIGEN BIOTECHNOLOGY CO., LTD.; 7f., No. 138, Xinming Rd., Neihu Dist. Taipei City, 114, TW
Inventors:
HSU, Ming-chu; TW
LIN, Chu-chung; TW
YEN, Chi-feng; TW
HSU, Han-pei; TW
CHEN, Wen-chang; TW
CHOU, Shan-yen; TW
Agent:
CORLESS, Peter, F.; US
ADAMS, Lisa; US
AZRIN, Linda, B.; US
BAUER, John, A.; US
AMENDT, Kevin, C.; US
Priority Data:
15/674,93711.08.2017US
Title (EN) TRANS-ISOMERIC HETEROCYCLIC COMPOUNDS AND PREPARATION THEREOF
(FR) NOUVEAUX COMPOSÉS TRICYCLIQUES ISOMÈRES TRANS ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract:
(EN) Provided is a trans-isomeric compound of formula (I) below or a pharmaceutically acceptable salt thereof, in which R1 is C1-C5 alkyl or C3-C5 cycloalkyl. The trans-isomeric compound has a trans:cis ratio of at least 70:30. Further provided is a method for preparing the trans-isomeric compound.
(FR) L'invention concerne un composé trans-isomère de formule (I) ci-dessous ou un sel pharmaceutiquement acceptable de celui-ci, dans laquelle R1 représente un groupe alkyle C1-C5 ou cycloalkyle C3-C5. Le composé isomère trans a un rapport trans:cis d'au moins 70:30. L'invention concerne en outre un procédé de préparation du composé isomère trans.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)