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1. (WO2019048881) OLIGONUCLEOTIDES COMPRISING TRIAZOLE AND (PHOSPHOR)AMIDATE INTERNUCLEOSIDE LINKAGES, METHOD FOR THE PREPARATION AND USES THEREOF
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Pub. No.: WO/2019/048881 International Application No.: PCT/GB2018/052555
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C07H 1/00 (2006.01) ,C07H 21/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1
Processes for the preparation of sugar derivatives
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants:
OXFORD UNIVERSITY INNOVATION LIMITED [GB/GB]; Buxton Court 3 West Way Botley Oxford Oxfordshire OX2 0JB, GB
Inventors:
BROWN, Tom; GB
EL-SAGHEER, Afaf Helmy; GB
Agent:
HGF LIMITED; 4th Floor, Merchant Exchange 17-19 Whitworth Street West Manchester Greater Manchester M1 5WG, GB
Priority Data:
1714403.107.09.2017GB
Title (EN) OLIGONUCLEOTIDES COMPRISING TRIAZOLE AND (PHOSPHOR)AMIDATE INTERNUCLEOSIDE LINKAGES, METHOD FOR THE PREPARATION AND USES THEREOF
(FR) OLIGONUCLÉOTIDES COMPRENANT DES LIAISONS INTERNUCLÉOSIDIQUES DE TYPE TRIAZOLE ET (PHOSPHORE)AMIDATE, LEUR PROCÉDÉ DE PRÉPARATION ET LEURS UTILISATIONS
Abstract:
(EN) The present invention relates to a process for preparing oligonucleotides or oligonucleotide analogues comprising triazole and (phosphor)amidate internucleoside linkages. The present invention also relates to the oligonucleotides and oligonucleotide analogues formed from said process and to the use of these oligonucleotides and oligonucleotide analogues in the synthesis of genes, as therapeutics in treatment of certain diseases and disorders (e.g. cancer) and as templates in polymerase chain reactions, DNA replication processes, RNA transcription processes and/or translation processes.
(FR) La présente invention concerne un procédé de préparation d'oligonucléotides ou d'analogues d'oligonucléotides comprenant des liaisons internucléosidiques de type triazole et (phosphore)amidate. La présente invention concerne également des oligonucléotides et analogues d'oligonucléotides formés à partir dudit procédé et l'utilisation de ces oligonucléotides et analogues d'oligonucléotides dans la synthèse de gènes, en tant qu'agents thérapeutiques destinés à être utilisés dans le traitement de certaines maladies et troubles (par exemple le cancer) et en tant que modèles dans des réactions en chaîne de la polymérase, des processus de réplication d'ADN, des processus de transcription d'ARN et/ou des processus de traduction.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)