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1. (WO2019048871) PROTEIN DELIVERY TO MEMBRANES
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Pub. No.: WO/2019/048871 International Application No.: PCT/GB2018/052534
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C07K 14/00 (2006.01) ,C07K 14/705 (2006.01) ,A61K 38/00 (2006.01) ,A61K 47/50 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
[IPC code unknown for A61K 47/50]
Applicants:
THE UNIVERSITY OF BRISTOL [GB/GB]; Senate House Tyndall Avenue Bristol BS8 1TH, GB
Inventors:
PERRIMAN, Adam, Willis; GB
DELLER, Robert, Christopher; GB
XIAO, Wenjin; GB
GREEN, Thomas, Iain, Phillip; GB
CARTER, Benjamin, Michael; GB
DAY, Graham, John; GB
DELINT, Rosalia, Cuahtecontzi; GB
Agent:
TURNER, Rhiannon; GB
Priority Data:
1714485.808.09.2017GB
1714566.511.09.2017GB
Title (EN) PROTEIN DELIVERY TO MEMBRANES
(FR) ADMINISTRATION DE PROTÉINES À DES MEMBRANES
Abstract:
(EN) There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a -CH2C(O)NCH3(CH2)3N(CH3)2H+ linker covalently bonded to an amino acid side chain.
(FR) L'invention concerne une composition de phospholipide qui est une bicouche ou une micelle comprenant au moins un conjugué de tensioactif protéine-polymère incorporé comprenant une protéine d'ancrage, la protéine d'ancrage étant une protéine cationisée ou une protéine anionisée, la composition étant caractérisée en ce que la protéine d'ancrage est : a) une enzyme active ; ou b) une protéine qui ne comprend pas un lieur -CH2C(O)NCH3(CH2)3N(CH3)2H+ lié de manière covalente à une chaîne latérale d'acide aminé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)