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1. (WO2019048666) POLYPEPTIDES FOR THE TREATMENT OF DISEASES
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Pub. No.: WO/2019/048666 International Application No.: PCT/EP2018/074272
Publication Date: 14.03.2019 International Filing Date: 10.09.2018
IPC:
C07K 7/08 (2006.01) ,A61K 38/00 (2006.01) ,C12N 5/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
08
having 12 to 20 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
Applicants:
NEOPEP PHARMA GMBH & CO. KG [DE/DE]; Feodor-Lynen-Str. 31 30625 Hannover, DE
Inventors:
FORSSMANN, Wolf-Georg; DE
Agent:
DOMPATENT VON KREISLER SELTING WERNER - PARTNERSCHAFT VON PATENTANWÄLTEN UND RECHTSANWÄLTEN MBB; Deichmannhaus am Dom Bahnhofsvorplatz 1 50667 Köln, DE
Priority Data:
17190152.308.09.2017EP
17205238.304.12.2017EP
Title (EN) POLYPEPTIDES FOR THE TREATMENT OF DISEASES
(FR) POLYPEPTIDES POUR LE TRAITEMENT DE MALADIES
Abstract:
(EN) A polypeptide having the general amino acid sequence written in the single letter code Z1 I X2 R W X5 X6 K X8 P X10 X11 S Z3, wherein X2 = V, M or L, in particular L, X5 = S or T, X6 = K or R, in particular R, X8 = V, M, L or F, in particular M, X10 = Q or C, in particular C, X11 = V, M or F, in particular V; Z1 = 0, Z2, or pyro glutamate, wherein Z2 = is a modification of the N-terminal nitrogen atom of the peptide chain which modification forms together with the amino group of the N-terminal amino acid of the peptide a moiety having the structure -NR2R3 wherein R2 and/or R3 are independently from each other H or a substituted or unsubstitued acyl, alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; Z3 = 0, or Z4, wherein Z4 = is a modification of the C-terminal carboxyl group of the peptide chain, which modification forms together with the carboxyl group of the C-terminal amino acid of the peptide a moiety having the structure -C(O)-O-R1 or -C(O)- NR2R3, wherein R1 is a substituted or unsubstitued alkyl, aryl, aralkyl, cyclo alkyl and heterocyclo alkyl group; and R2 and R3 are defined as above.
(FR) La présente invention concerne un polypeptide ayant la séquence générale d'acides aminés écrite sous forme de code alphabétique unique Z1 I X2 R W X5 X6 K X8 P X10 X11 S Z3, X2 = V, M ou L, en particulier L, X5 = S ou T, X6 = K ou R, en particulier R, X8 = V, M, L ou F, en particulier M, X10 = Q ou C, en particulier C, X11 = V, M ou F, en particulier V ; Z1 = 0, Z2, ou pyro glutamate, Z2 = étant une modification de l'atome d'azote N-terminal de la chaîne peptidique, laquelle modification forme conjointement avec le groupe amino de l'acide aminé N-terminal du peptide une fraction ayant la structure -NR2R3, R2 et/ou R3 étant indépendamment les uns des autres H ou un groupe acyle, alkyle, aryle, aralkyle, cycloalkyle et hétérocycloalkyle substitué ou non substitué ; Z3 = 0, ou Z4, Z4 = étant une modification du groupe carboxyle C-terminal de la chaîne peptidique, laquelle modification forme conjointement avec le groupe carboxyle de l'acide aminé C-terminal du peptide une fraction ayant la structure -C(O)-O-R1 ou -C(O)- NR2R3, R1 étant un groupe alkyle, aryle, aralkyle, cycloalkyle et hétérocycloalkyle substitué ou non substitué ; et R2 et R3 sont tels que définis ci-dessus.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)