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1. (WO2019048645) STABILIZED CEBPA SARNA COMPOSITIONS AND METHODS OF USE
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Pub. No.: WO/2019/048645 International Application No.: PCT/EP2018/074211
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12N 15/113 (2010.01) ,A61K 31/713 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
Applicants:
MINA THERAPEUTICS LIMITED [GB/GB]; Translation & Innovation Hub 80 Wood Lane London W12 0BZ, GB
Inventors:
HUBER, Hans E.; US
BLAKEY, David; GB
VOUTILA, Jon; GB
REEBYE, Vikash; GB
Agent:
CHAPMAN, Desmond Mark; GB
JACKSON, Richard Eric; GB
COCKERTON, Bruce Roger; GB
MARSHALL, Cameron John; GB
GOODFELLOW, Hugh Robin; GB
TUNSTALL, Christopher Stephen; GB
KIRSCH, Susan Edith; GB
SMALL, Gary James; GB
WARNER, James Alexander; GB
BRUNNER, John Michael Owen; GB
CHAPMAN, Desmond Mark; GB
WISE, Daniel Joseph; GB
OATES, Edward Christopher; GB
MCGUIRE, Gillian Margaret; GB
MORRIS, Claire Louise; GB
COX, Jennifer Jane; GB
GEORGIOU, Matthew; GB
HOLLAND, David Christopher; GB
BETTRIDGE, Paul Sebastian; GB
DRAGOSAVAC, Susannah Marie; GB
PREISSNER, Tanja Stephanie; GB
LEATHLEY, Anna Elisabeth; GB
FISHER, John William; GB
HUSBAND, Benjamin; GB
DUFFIELD, Stephen; GB
MACLEOD, Ian Roger; GB
HOGGETT, Christopher James; GB
GRABENSTEIN, Jens; GB
MICHELL, Stephen Robert; GB
DARBY, Richard John; GB
BARRY, Isobel Amy; GB
MCKINLEY, Elizabeth Anne; GB
BIRCH, Matthew John; GB
THEISEN, Andreas Robert; GB
Priority Data:
62/555,95108.09.2017US
Title (EN) STABILIZED CEBPA SARNA COMPOSITIONS AND METHODS OF USE
(FR) COMPOSITIONS STABILISÉES DE PETITS ARN ACTIVATEURS (PARNA) DE CEBPA ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention relates to modified oligonucleotides, e.g., saRNAs useful in upregulating the expression of a target gene and therapeutic compositions comprising such oligonucleotides. Methods of using the oligonucleotides and the therapeutic compositions are also provided.
(FR) L'invention concerne des oligonucléotides modifiés, par exemple, des pARNa utiles pour la régulation à la hausse de l'expression d'un gène cible et des compositions thérapeutiques contenant ces oligonucléotides. L'invention concerne également des procédés d'utilisation des oligonucléotides et des compositions thérapeutiques les contenant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)