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1. (WO2019048640) COMBINATION THERAPIES OF HEPATITIS B VIRUS (HBV)-INFECTED INDIVIDUALS USING PARAPOXVIRUS OVIS (PPVO) AND AT LEAST ONE FURTHER ANTIVIRAL DRUG
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Pub. No.: WO/2019/048640 International Application No.: PCT/EP2018/074202
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
A61K 39/12 (2006.01) ,A61P 37/02 (2006.01) ,A61P 31/20 (2006.01) ,A61K 31/522 (2006.01) ,A61K 31/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
522
having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
Applicants:
AICURIS GMBH & CO. KG [DE/DE]; Friedrich-Ebert-Straße 475 42117 Wuppertal, DE
Inventors:
PAULSEN, Daniela; DE
URBAN, Andreas; DE
ADDY, Ibironke; DE
PFAFF, Tamara; DE
MENNE, Stephan; US
SLOOT, Willem; DE
Agent:
BOEHMERT & BOEHMERT; KILGER, Ute Hollerallee 32 28209 Bremen, DE
Priority Data:
17189890.107.09.2017EP
17196684.916.10.2017EP
Title (EN) COMBINATION THERAPIES OF HEPATITIS B VIRUS (HBV)-INFECTED INDIVIDUALS USING PARAPOXVIRUS OVIS (PPVO) AND AT LEAST ONE FURTHER ANTIVIRAL DRUG
(FR) POLYTHÉRAPIES POUR DES INDIVIDUS ATTEINTS D'UNE INFECTION AU VIRUS DE L'HÉPATITE B (VHB) UTILISANT PARAPOXVIRUS OVIS (PPVO) ET AU MOINS UN AUTRE MÉDICAMENT ANTIVIRAL
Abstract:
(EN) The present invention relates to new combination therapies of HBV-infected individuals using a Parapoxvirus ovis (PPVO) and at least one further antiviral drug, e.g., nucleoside inhibitors, such as Entecavir. The methods and combination products according to the present invention are safe and suitable for the induction of a functional cure in chronically HBV-infected patients.
(FR) La présente invention concerne de nouvelles polythérapies pour des individus atteints d'une infection au VHB utilisant Parapoxvirus ovis (PPVO) et au moins un autre médicament antiviral, par exemple, des inhibiteurs nucléosidiques, notamment l'Entecavir. Les procédés et les produits de polythérapie selon la présente invention sont sûrs et appropriés pour l'induction d'une guérison fonctionnelle chez des patients atteints d'une infection chronique au VHB.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)