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1. (WO2019048632) STABILIZED HNF4A SARNA COMPOSITIONS AND METHODS OF USE
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Pub. No.: WO/2019/048632 International Application No.: PCT/EP2018/074192
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12N 15/113 (2010.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
Applicants:
MINA THERAPEUTICS LIMITED [GB/GB]; Translation & Innovation Hub 80 Wood Lane London W12 0BZ, GB
Inventors:
HUBER, Hans E.; US
BLAKEY, David; GB
VOUTILA, Jon; GB
REEBYE, Vikash; GB
Agent:
CHAPMAN, Desmond Mark; GB
JACKSON, Richard Eric; GB
COCKERTON, Bruce Roger; GB
MARSHALL, Cameron John; GB
GOODFELLOW, Hugh Robin; GB
TUNSTALL, Christopher Stephen; GB
KIRSCH, Susan Edith; GB
SMALL, Gary James; GB
WARNER, James Alexander; GB
BRUNNER, John Michael Owen; GB
CHAPMAN, Desmond Mark; GB
WISE, Daniel Joseph; GB
OATES, Edward Christopher; GB
MCGUIRE, Gillian Margaret; GB
MORRIS, Claire Louise; GB
COX, Jennifer Jane; GB
GEORGIOU, Matthew; GB
HOLLAND, David Christopher; GB
BETTRIDGE, Paul Sebastian; GB
DRAGOSAVAC, Susannah Marie; GB
PREISSNER, Tanja Stephanie; GB
LEATHLEY, Anna Elisabeth; GB
FISHER, John William; GB
HUSBAND, Benjamin; GB
DUFFIELD, Stephen; GB
MACLEOD, Ian Roger; GB
HOGGETT, Christopher James; GB
GRABENSTEIN, Jens; GB
MICHELL, Stephen Robert; GB
DARBY, Richard John; GB
BARRY, Isobel Amy; GB
MCKINLEY, Elizabeth Anne; GB
BIRCH, Matthew John; GB
THEISEN, Andreas Robert; GB
Priority Data:
62/555,93708.09.2017US
62/555,95108.09.2017US
PCT/EP2017/07413022.09.2017EP
Title (EN) STABILIZED HNF4A SARNA COMPOSITIONS AND METHODS OF USE
(FR) COMPOSITIONS STABILISÉES DE PETITS ARN ACTIVATEURS (PARNA) DE HNF4A ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) The invention relates to saRNA targeting an HNF4a transcript and therapeutic compositions comprising said saRNA. Methods of using the therapeutic compositions are also provided.
(FR) L'invention concerne un petit ARN activateur (pARNa) ciblant un transcrit de HNF4a et des compositions thérapeutiques contenant ledit pARNa. L'invention concerne également des procédés d'utilisation des compositions thérapeutiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)