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1. (WO2019048588) MIXED PROTEIN AND AUTOANTIBODY BIOMARKER PANEL FOR DIAGNOSING COLORECTAL CANCER
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Pub. No.: WO/2019/048588 International Application No.: PCT/EP2018/074087
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS [DE/DE]; Im Neuenheimer Feld 280 69120 Heidelberg, DE
Inventors:
BRENNER, Hermann; DE
CHEN, Hongda; CN
Agent:
BOEHMERT & BOEHMERT; KUTTENKEULER, David Pettenkoferstrasse 22 80336 Munich, DE
Priority Data:
17190007.907.09.2017EP
Title (EN) MIXED PROTEIN AND AUTOANTIBODY BIOMARKER PANEL FOR DIAGNOSING COLORECTAL CANCER
(FR) PANEL DE BIOMARQUEURS DE PROTÉINES ET D'AUTO-ANTICORPS MIXTE POUR LE DIAGNOSTIC DU CANCER COLORECTAL
Abstract:
(EN) The present invention pertains to a new method for the diagnosis, prognosis, stratification and/or monitoring of a therapy, of cancer, preferably colorectal cancer, in a patient. The method is based on the determination of the level of a panel of least four biomarker selected from the group consisting of the protein biomarker AREG, GDF-15, FasL, Flt3L, and the autoantibody biomarker TP53 -autoantibody. The new biomarker panel of the invention allows diagnosing and even stratifying various cancer diseases. Furthermore provided are diagnostic kits for performing the non- invasive methods of the invention.
(FR) La présente invention concerne une nouvelle méthode pour le diagnostic, le pronostic, la stratification et/ou la surveillance d'une thérapie du cancer, de préférence du cancer colorectal, chez un patient. La méthode repose sur la détermination du niveau d'un panel d'au moins quatre biomarqueurs choisis dans le groupe constitué par le biomarqueur de protéine AREG, GDF-15, FasL, Flt3L, et le biomarqueur d'auto-anticorps de l'auto-anticorps TP53. Le nouveau panel de biomarqueurs selon l'invention permet de diagnostiquer et même de stratifier plusieurs maladies cancéreuses. L'invention concerne également des kits de diagnostic permettant la mise en œuvre des méthodes non invasives de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)