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1. (WO2019048526) PROCESS FOR THE PREPARATION OF 1-[6-HALOGENO-3-PYRIDYL]KETONES
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Pub. No.: WO/2019/048526 International Application No.: PCT/EP2018/073963
Publication Date: 14.03.2019 International Filing Date: 06.09.2018
IPC:
C07D 213/78 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
78
Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants:
BAYER AKTIENGESELLSCHAFT [DE/DE]; Kaiser-Wilhelm-Allee 1 51373 Leverkusen, DE
Inventors:
SCHOTES, Christoph; DE
Agent:
BIP PATENTS; Alfred-Nobel-Str. 10 40789 Monheim am Rhein NRW, DE
Priority Data:
17190359.411.09.2017EP
Title (EN) PROCESS FOR THE PREPARATION OF 1-[6-HALOGENO-3-PYRIDYL]KETONES
(FR) PROCÉDÉ DE PRÉPARATION DE 1-[6-HALOGÉNO-3-PYRIDYL]CÉTONES
Abstract:
(EN) The present invention relates to a process for preparing a compound of formula (I) wherein R represents hydrogen, C1-C2-halogenalkyl, C1-C2-halogenalkoxy, C1-C2-alkylcarbonyl, fluorine or chlorine, R1 represents C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, C3-C8-cycloalkyl-C1-C4-alkyl, phenyl, phenyl-C1-C4-alkyl, phenyl-C2-C4-alkenyl or phenyl-C2-C4-alkynyl and X represents fluorine or chlorine; by reacting a compound of formula (II) in a first step A) with a compound of formula R'MgY (III), wherein R represents C1-C6-alkyl or C3-C8-cycloalkyl; and Y represents chlorine or bromine; and in step B) with an anhydride of formula (IV) and optionally further reacting the compound of formula (I) to a triazole derivative of formula (VI).
(FR) La présente invention concerne un procédé de préparation d'un composé de formule (I) dans laquelle R représente hydrogène, halogénoalkyle en C1-C2, halogénoalcoxy en C1-C2, alkylcarbonyle en C1-C2, fluor ou chlore, R1 représente alkyle en C1-C6, alcényle en C2-C6, alcynyle en C2-C6, cycloalkyle en C3-C8, C3-C8-cycloalkyl-C1-C4-alkyle, phényle, phényl-C1-C4-alkyle, phényl-C2-C4-alcényle ou phényl-C2-C4-alcynyle et X représente du fluor ou du chlore ; en faisant réagir un composé de formule (II) dans une première étape A) avec un composé de formule R'MgY (III), dans laquelle R représente alkyle en C1-C6 ou cycloalkyle en C3-C8 ; et Y représente chlore ou brome ; et une étape B) avec un anhydride de formule (IV) et éventuellement faire réagir le composé de formule (I) avec un dérivé de triazole de formule (VI).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)