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1. (WO2019048461) BIOMARKERS FOR PREDICTING RESPONSE TO CLOSTRIDIUM DIFFICILE
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Pub. No.: WO/2019/048461 International Application No.: PCT/EP2018/073837
Publication Date: 14.03.2019 International Filing Date: 05.09.2018
IPC:
A61K 39/08 (2006.01) ,C12Q 1/6851 (2018.01) ,G01N 33/569 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
08
Clostridium, e.g. Clostridium tetani
[IPC code unknown for C12Q 1/6851]
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
BIOSYS UK LIMITED [GB/GB]; 2 Queen Anne's Gate Buildings Third Floor Dartmouth Street London Greater London SW1H 9BP, GB
Inventors:
PFAFFL, Michael; DE
HILLREINER, Maria; DE
KLIEM, Heike; DE
Agent:
WESCOTT, Rhiannon; GB
ADDISS, John; GB
ANDREWS, Robert; GB
BAILEY, Sam; GB
BREARLEY, Sarah; GB
BURNS, Alexander; GB
CARLISLE, Julie; GB
CASLEY, Christopher; GB
CLEGG, Richard; GB
CRIPPS, Joanna; GB
DALE, Elizabeth; GB
DENISON, Christopher; GB
DUNNE, Paul; GB
FORREST, Graham; GB
FURNIVAL, Tom; GB
GILL, Stephen; GB
GRAHAM, Emma; GB
GREEN, Katherine; GB
GREGORY, Adam; GB
HARRISON, Susan; GB
HAYES, Emily; GB
HODSDON, Stephen; GB
JOHNSON, Richard; GB
JONES, Rachel; GB
KEIRSTEAD, Tanis; GB
KIDDLE, Simon; GB
KREMER, Simon; GB
LEACH, James; GB
LENTHALL, Joseph; GB
LYONS, June; GB
MACIVER, Eleanor; GB
MCGUINN, Callum; GB
MOELLER, Christoph; GB
MOORE, Graeme; GB
NAYLOR, Matthew; GB
OXLEY, Rachel; GB
PARRY, Simon; GB
SALISBURY, Frances; GB
SMITH, Matthew; GB
STONER, Patrick; GB
SUTCLIFFE, Nicholas; GB
THORNTON, Dan; GB
TOLLERVEY, Rebecca; GB
WALTON, Seán; GB
WARD, Eliot; GB
WATSON, Robert; GB
WEBSTER, Jeremy; GB
WILLS, Jonathan; GB
WYTENBURG, Wilhelmus; GB
Priority Data:
1714220.905.09.2017GB
Title (EN) BIOMARKERS FOR PREDICTING RESPONSE TO CLOSTRIDIUM DIFFICILE
(FR) BIOMARQUEURS POUR PRÉDIRE UNE RÉPONSE À CLOSTRIDIUM DIFFICILE
Abstract:
(EN) The invention relates to methods for identifying/selecting cows for immunisation and to the use of markers for such methods. The methods involve interrogation of cells from a cow, and the use of markers in those cells to identify cows for immunisation. Cows are selected for immunisation by observing the change in expression of markers resulting from stimulating a cell obtained from a cow with C. difficile and/or a C. difficile specific antigen.
(FR) L'invention concerne des méthodes permettant d'identifier/de sélectionner des vaches devant être immunisées, et l'utilisation de marqueurs pour de telles méthodes. Les méthodes impliquent l'examen de cellules provenant d'une vache, et l'utilisation de marqueurs sur ces cellules pour identifier les vaches devant être immunisées. Les vaches sont sélectionnées pour être immunisées en observant le changement de l'expression de marqueurs résultant de la stimulation d'une cellule provenant d'une vache par C. difficile et/ou par un antigène spécifique de C. difficile.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)