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1. WO2019048450 - SULFOXIDE-BASED REAGENT FOR MASS SPECTROMETRY

Publication Number WO/2019/048450
Publication Date 14.03.2019
International Application No. PCT/EP2018/073812
International Filing Date 05.09.2018
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
C07C 317/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
16having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
18with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
CPC
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07C 317/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
317Sulfones; Sulfoxides
44having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
48the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
50at least one of the nitrogen atoms being part of any of the groups , X being a hetero atom, Y being any atom
C07D 207/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
46with hetero atoms directly attached to the ring nitrogen atom
G01N 33/58
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
G01N 33/6848
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6803General methods of protein analysis not limited to specific proteins or families of proteins
6848Methods of protein analysis involving mass spectrometry
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH]
Inventors
  • CARELL, Thomas
Agents
  • WEICKMANN & WEICKMANN PARTMBB
Priority Data
17190147.308.09.2017EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SULFOXIDE-BASED REAGENT FOR MASS SPECTROMETRY
(FR) RÉACTIF À BASE DE SULFOXYDE POUR SPECTROMÉTRIE DE MASSE
Abstract
(EN)
The present invention relates to sulfoxide-based reagents suitable in the mass spectrometric determination of analyte molecules such as peptides as well as adducts of such reagents and analyte molecules and applications of said reagents and adducts. Further, the present invention relates to methods for the mass spectrometric determination of analyte molecules.
(FR)
La présente invention concerne des réactifs à base de sulfoxyde appropriés pour la détermination par spectrométrie de masse de molécules d'analyte telles que des peptides ainsi que des adduits de ces réactifs et molécules d'analyte et des applications desdits réactifs et adduits. L'invention concerne en outre des procédés de détermination par spectrométrie de masse de molécules d'analyte.
Also published as
JP2020513843
Latest bibliographic data on file with the International Bureau