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1. (WO2019048068) COMBINATION OF STRUCTURAL VARIATIONS AND SINGLE NUCLEOTIDE CHANGES IN ONE STATISTICAL MODEL FOR IMPROVED ANTIMICROBIAL DRUG THERAPY SELECTION
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Pub. No.: WO/2019/048068 International Application No.: PCT/EP2017/072757
Publication Date: 14.03.2019 International Filing Date: 11.09.2017
IPC:
C12Q 1/689 (2018.01) ,G06F 19/18 (2011.01) ,G06F 19/22 (2011.01)
[IPC code unknown for C12Q 1/689]
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
18
for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
22
for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or SNP [Single-Nucleotide Polymorphism] discovery or sequence alignment
Applicants:
ARES GENETICS GMBH [AT/AT]; Karl-Farkas-Gasse 18 1030 Vienna, AT
Inventors:
BACKES, Christina; DE
GALATA, Valentina; DE
KELLER, Andreas; DE
SCHMOLKE, Susanne; DE
STÄHLER, Cord Friedrich; DE
Agent:
SCHNAPPAUF, Georg; DE
Priority Data:
Title (EN) COMBINATION OF STRUCTURAL VARIATIONS AND SINGLE NUCLEOTIDE CHANGES IN ONE STATISTICAL MODEL FOR IMPROVED ANTIMICROBIAL DRUG THERAPY SELECTION
(FR) COMBINAISON DE VARIATIONS STRUCTURELLES ET DE MODIFICATIONS DE NUCLÉOTIDES SIMPLES DANS UN MODÈLE STATISTIQUE POUR UNE SÉLECTION DE TRAITEMENT MÉDICAMENTEUX ANTIMICROBIEN AMÉLIORÉE
Abstract:
(EN) The invention relates to a method of determining an antimicrobial drug resistance profile for a microorganism, wherein nucleic acid sequences of the microorganism are analyzed for structural variations of the genome comprising at least a change in the genome comprising more than one base, as well as for single nucleotide polymorphisms (SNPs), as well as a method of determining an infection of a patient with a microorganism potentially resistant to antimicrobial drug treatment and a method of selecting a treatment of a patient suffering from an infection with a potentially resistant microorganism, wherein the data of the antimicrobial drug resistance profile are applied.
(FR) La présente invention concerne une méthode de détermination d’un profil de résistance au médicament antimicrobien pour un micro-organisme, les séquences d’acides nucléiques du micro-organisme étant analysées pour des variations structurelles du génome comprenant au moins un changement dans le génome comprenant plus d'une base, ainsi que pour des polymorphismes mononucléotidiques (SNP), ainsi qu'une méthode de détermination d'une infection d'un patient par un micro-organisme potentiellement résistant à un traitement medicamenteux antimicrobien et une méthode de sélection d'un traitement d'un patient souffrant d'une infection par un micro-organisme potentiellement résistant, les données du profil de résistance au médicament antimicrobien étant appliquées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)