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1. (WO2019047932) GENETICALLY ENGINEERED T CELL AND APPLICATION THEREOF
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Pub. No.: WO/2019/047932 International Application No.: PCT/CN2018/104669
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12N 15/87 (2006.01) ,A61K 48/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
科济生物医药(上海)有限公司 CARSGEN THERAPEUTICS CO., LTD. [CN/CN]; 中国上海市 徐汇区银都路388号B栋 Building B, No. 388 Yindu Raod, Xuhui District Shanghai 200231, CN
上海市肿瘤研究所 SHANGHAI CANCER INSTITUTE [CN/CN]; 中国上海市 徐汇区斜土路2200弄25号 No. 25/Ln 2200 Xietu Road, Xuhui District Shanghai 200032, CN
Inventors:
李宗海 LI, Zonghai; CN
郭星亮 GUO, Xingliang; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS, LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room 106, Building No. 1, Universal High-Tech Plaza, 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201710805991.408.09.2017CN
201710867308.X22.09.2017CN
201711287300.207.12.2017CN
Title (EN) GENETICALLY ENGINEERED T CELL AND APPLICATION THEREOF
(FR) LYMPHOCYTE T GÉNÉTIQUEMENT MODIFIÉ ET SON APPLICATION
(ZH) 基因工程化的T细胞及应用
Abstract:
(EN) Provided are a genetically engineered T cell and a pharmaceutical composition using the same. The T cell has an endogenous T cell receptor (TCR) that is inactivated or inactive, comprises encoding of an exogenous receptor bindable to a target antigen, and contains an open reading frame regulated by the exogenous receptor. When the exogenous receptor binds to the target antigen, expression of the open reading frame can be initiated. The T cell has a killing effect on tumor cells and has reduced side effects and enhanced safety.
(FR) L'invention concerne un lymphocyte T génétiquement modifié et une composition pharmaceutique l'utilisant. Le lymphocyte T comporte un récepteur de lymphocyte T endogène (TCR) qui est inactivé ou inactif, comprend le codage d'un récepteur exogène pouvant se lier à un antigène cible, et contient un cadre de lecture ouvert régulé par le récepteur exogène. Lorsque le récepteur exogène se lie à l'antigène cible, l'expression du cadre de lecture ouvert peut être initiée. Le lymphocyte T a un effet destructeur sur des cellules tumorales et présente des effets secondaires réduits et une sécurité améliorée.
(ZH) 提供了一种基因工程化的T细胞及其药物组合物,所述T细胞的内源性T细胞受体(TCR)失活或者不具有活性,同时包含编码可结合靶抗原的外源性受体,及受所述外源性受体调控的开放阅读框,当所述外源性受体结合所述靶抗原,能够启动所述开放阅读框的表达。所述T细胞具备对肿瘤细胞的杀伤效果,并且副作用降低,安全性增强。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)