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1. (WO2019047914) DOUBLE-STRANDED RNA MOLECULE TARGETING CKIP-1 AND USE THEREOF
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Pub. No.: WO/2019/047914 International Application No.: PCT/CN2018/104552
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
IPC:
C12N 15/11 (2006.01) ,C12N 15/63 (2006.01) ,A61K 48/00 (2006.01) ,A61P 19/02 (2006.01) ,A61P 19/08 (2006.01) ,A61P 19/10 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
Applicants:
北京泰德制药股份有限公司 BEIJING TIDE PHARMACEUTICAL CO., LTD. [CN/CN]; 中国北京市 北京经济技术开发区荣京东街8号 No.8 East Rongjing Street, BDA Beijing 100176, CN
Inventors:
赵焰平 ZHAO, Yanping; CN
王红军 WANG, Hongjun; CN
姜媛媛 JIANG, Yuanyuan; CN
仲伟婷 ZHONG, Weiting; CN
庞建梅 PANG, Jianmei; CN
李功 LI, Gong; CN
李想 LI, Xiang; CN
何伊欣 HE, Yixin; CN
周丽莹 ZHOU, Liying; CN
刘亚男 LIU, Yanan; CN
Agent:
北京永新同创知识产权代理有限公司 NTD UNIVATION INTELLECTUAL PROPERTY AGENCY LTD.; 中国北京市 东城区北三环东路36号北京环球贸易中心C座10层 10th Floor Tower C, Beijing Global Trade Center, 36 North Third Ring Road East, Dongcheng District Beijing 100013, CN
Priority Data:
PCT/CN2017/10086307.09.2017CN
PCT/CN2017/10086407.09.2017CN
PCT/CN2017/10086507.09.2017CN
PCT/CN2017/10086607.09.2017CN
PCT/CN2017/10086707.09.2017CN
Title (EN) DOUBLE-STRANDED RNA MOLECULE TARGETING CKIP-1 AND USE THEREOF
(FR) MOLÉCULE D'ARN DOUBLE BRIN CIBLANT CKIP-1 ET SON UTILISATION
(ZH) 靶向CKIP-1的双链RNA分子及其用途
Abstract:
(EN) Provided are a double-stranded RNA molecule targeting CKIP-1 and a use thereof in treating an inflammatory disease including rheumatoid arthritis.
(FR) L'invention concerne une molécule d'ARN double brin ciblant CKIP-1 et son utilisation dans le traitement d'une maladie inflammatoire comprenant la polyarthrite rhumatoïde.
(ZH) 提供了一种靶向CKIP-1的双链RNA分子及其在治疗包括类风湿关节炎在内的炎症疾病方面的用途。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)