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1. (WO2019047686) CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS
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Pub. No.: WO/2019/047686 International Application No.: PCT/CN2018/100515
Publication Date: 14.03.2019 International Filing Date: 14.08.2018
IPC:
C07D 401/14 (2006.01) ,A61K 31/4196 (2006.01) ,A61K 31/44 (2006.01) ,A61P 1/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4196
1,2,4-Triazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
16
for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285, US
LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD. [CN/CN]; Rm. 819, 780 Cailun Road Zhangjiang, High Technology Park, Pudong New Area Shanghai 201203, CN (MG)
Inventors:
LIU, Lian Zhu; US
ZHANG, Haizhen; US
WANG, Xiaoqing; US
LIU, Gang; US
Agent:
LEE AND LI - LEAVEN IPR AGENCY LTD.; Unit 2202, Tower A, Beijing Marriott Center No. 7 Jian Guo Men South Avenue Beijing 100005, CN
Priority Data:
PCT/CN2017/10085807.09.2017CN
Title (EN) CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS
(FR) COMPOSÉS DE CYCLOBUTYLE-IMIDAZOLIDINONE
Abstract:
(EN) Provided are compounds of Formula (I), pharmaceutically acceptable salt thereof, compositions and methods to treat liver disease and NASH.
(FR) L'invention concerne des composés de formule (I), un sel pharmaceutiquement acceptable de ceux-ci, des compositions et des méthodes de traitement d'une maladie hépatique et d'une NASH.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)