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1. (WO2019047368) MIRNA TARGETING CJUN SIGNALING PATHWAY AND PREPARATION METHOD THEREFOR AND USE THEREOF
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Pub. No.: WO/2019/047368 International Application No.: PCT/CN2017/111054
Publication Date: 14.03.2019 International Filing Date: 15.11.2017
IPC:
C12N 15/113 (2010.01) ,C12N 15/867 (2006.01) ,C12N 7/01 (2006.01) ,C12Q 1/68 (2018.01) ,A61K 31/7088 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
867
Retroviral vectors
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
01
Viruses, e.g. bacteriophages, modified by introduction of foreign genetic material
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
Applicants:
中国科学院深圳先进技术研究院 SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国广东省深圳市 南山区深圳大学城学苑大道1068号 No. 1068, Xueyuan Avenue, Shenzhen University Town, Nanshan District Shenzhen, Guangdong 518055, CN
Inventors:
钱政江 QIAN, Zhengjiang; CN
李翔 LI, Xiang; CN
杨海洋 YANG, Haiyang; CN
Agent:
北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW; 中国北京市 海淀区莲花池东路39号西金大厦6层 F6, Xijin Centre 39 Lianhuachi East Rd., Haidian District Beijing 100036, CN
Priority Data:
201710807381.808.09.2017CN
Title (EN) MIRNA TARGETING CJUN SIGNALING PATHWAY AND PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) MIARN CIBLANT LA VOIE DE SIGNALISATION CJUN ET MÉTHODE DE PRÉPARATION ET UTILISATION ASSOCIÉES
(ZH) 一种靶向cJun信号通路的miRNA及其制备方法和应用
Abstract:
(EN) Disclosed is an miRNA targeting the cJun signaling pathway and a preparation method therefor and the use thereof. In particular, the present invention relates to a micromolecule RNA-miR-4632 targeted inhibiting the cJun gene and the use thereof. The nucleotide sequence of the miRNA is SEQ ID NO. 1 or a nucleotide sequence having at least 90% identity thereto. The miRNA has an endogenous, specific targeted inhibition of the cJun signaling pathway and can be used to prepare a drug that inhibits diseases caused by abnormal activation of the cJun-mediated signaling pathway.
(FR) L'invention concerne un miARN ciblant la voie de signalisation cJun, une méthode de préparation de celui-ci, et une utilisation associée. En particulier, la présente invention concerne une micro-molécule ARN-miR-4632 qui inhibe de manière ciblée le gène cJun et son utilisation. La séquence nucléotidique du miARN est la SEQ ID NO. 1 ou une séquence nucléotidique ayant au moins 90 % d'identité avec celle-ci. Le miARN a une inhibition ciblée spécifique endogène de la voie de signalisation cJun et peut être utilisé pour préparer un médicament qui inhibe des maladies provoquées par une activation anormale de la voie de signalisation médiée par cJun.
(ZH) 一种靶向cJun信号通路的miRNA及其制备方法和应用,具体涉及一种靶向抑制cJun基因的小分子RNA-miR-4632及其应用,所述miRNA的核苷酸序列为SEQ ID NO.1或与其具有至少90%同一性的核苷酸序列。所述miRNA具有内源性、特异性靶向抑制cJun信号通路,能够制备抑制由于cJun介导的信号通路异常激活所引起疾病的药物。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)