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1. (WO2019047299) TRANSDERMAL SHORT PEPTIDE HAVING NUCLEAR POSITIONING CAPABILITY AND APPLICATIONS THEREOF
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Pub. No.: WO/2019/047299 International Application No.: PCT/CN2017/105051
Publication Date: 14.03.2019 International Filing Date: 30.09.2017
IPC:
C07K 14/435 (2006.01) ,C07K 19/00 (2006.01) ,A61K 38/17 (2006.01) ,A61P 17/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants:
苏州大学 SOOCHOW UNIVERSITY [CN/CN]; 中国江苏省苏州市 相城区济学路8号 8#, Jixue Road, Xiangcheng Suzhou, Jiangsu 215100, CN
Inventors:
张舒羽 ZHANG, Shuyu; CN
曹建平 CAO, Jianping; CN
余道江 YU, Daojiang; CN
朱巍 ZHU, Wei; CN
王文洁 WANG, Wenjie; CN
Agent:
苏州市中南伟业知识产权代理事务所(普通合伙) CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE; 中国江苏省苏州市 工业园区若水路388号苏州纳米技术国家大学科技园H-216室 Room H216, Suzhou Nanotech National University Science Park No.388, Ruoshui Road, Industrial Park Suzhou, Jiangsu 215123, CN
Priority Data:
201710790765.305.09.2017CN
Title (EN) TRANSDERMAL SHORT PEPTIDE HAVING NUCLEAR POSITIONING CAPABILITY AND APPLICATIONS THEREOF
(FR) PEPTIDE COURT TRANSDERMIQUE AYANT UNE CAPACITÉ DE POSITIONNEMENT NUCLÉAIRE ET SES APPLICATIONS
(ZH) 具有核定位能力的透皮短肽及其应用
Abstract:
(EN) Provided is a transdermal short peptide having nuclear positioning capability, the amino acid sequence thereof being as represented by SEQ ID No. 1; also provided is a fusion protein having nuclear positioning capability, comprising a macromolecular protein, one end of the macromolecular protein being connected to the transdermal short peptide. Also disclosed are applications of the short peptide in preparing a medicament or a transdermal preparation for treating skin diseases. Further provided in the present invention is the medicament for treating skin diseases, comprising the transdermal short peptide and a pharmaceutically acceptable excipient.
(FR) L'invention concerne un peptide court transdermique ayant une capacité de positionnement nucléaire, la séquence d'acides aminés de celui-ci étant telle que représentée par SEQ ID No. 1.L'invention concerne également une protéine de fusion ayant une capacité de positionnement nucléaire, comprenant une protéine macromoléculaire, une extrémité de la protéine macromoléculaire étant reliée au peptide court transdermique.L'invention concerne en outre des applications du peptide court dans la préparation d'un médicament ou d'une préparation transdermique pour le traitement de maladies dermatologiques. La présente invention concerne par ailleurs un médicament pour le traitement de maladies dermatologiques, comprenant le peptide court transdermique et un excipient pharmaceutiquement acceptable.
(ZH) 本发明提供了一种具有核定位能力的透皮短肽,其氨基酸序列如SEQ ID No.1所示;还提供了一种具有核定位能力的融合蛋白,包括大分子蛋白,大分子蛋白的一端连接上述透皮短肽。还公开了上述透皮短肽在制备治疗皮肤病的药物或透皮制剂中的应用。本发明进一步提供了一种治疗皮肤病的药物,包括上述透皮短肽以及药学上可接受的辅料。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)