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1. WO2019047260 - CISATRACURIUM BESILATE COMPOSITION AND PREPARATION METHOD THEREFOR

Publication Number WO/2019/047260
Publication Date 14.03.2019
International Application No. PCT/CN2017/101868
International Filing Date 15.09.2017
IPC
A61K 9/19 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
19lyophilised
A61K 31/4725 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61K 47/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/32 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers
CPC
A61K 31/4725
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
472Non-condensed isoquinolines, e.g. papaverine
4725containing further heterocyclic rings
A61K 47/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 9/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
19lyophilised ; , i.e. freeze-dried, solutions or dispersions
Applicants
  • 上药东英(江苏)药业有限公司 SHANGHAI PHARMA, DONGYING (JIANGSU) PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 汪晓铭 WANG, Xiaoming
  • 周亚兵 ZHOU, Yabing
  • 孙伯兰 SUN, Bolan
  • 杜芳 DU, Fang
  • 陈晶晶 CHEN, Jingjing
  • 赵敏 ZHAO, Min
Priority Data
201710803195.708.09.2017CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CISATRACURIUM BESILATE COMPOSITION AND PREPARATION METHOD THEREFOR
(FR) COMPOSITION DE BÉSILATE DE CISATRACURIUM ET SON PROCÉDÉ DE PRÉPARATION
(ZH) 一种苯磺顺阿曲库铵组合物及其制备方法
Abstract
(EN)
Disclosed in the present invention are a cisatracurium besilate composition and a preparation method therefor, the cisatracurium besilate composition being composed of the following components by weight: 13-18 g of cisatracurium besilate; 25-30 g of an amino acid; 3-5 g of activated carbon for needles; 100-300 g of polyvinylpyrrolidone; a suitable amount of a pH adjusting agent; and adding water for injection to 2000 ml. The present invention reduces the atrophic sample ratio of the cisatracurium besilate composition, increases the qualification rate of a product, and reduces production costs.
(FR)
La présente invention concerne une composition de bésilate de cisatracurium et son procédé de préparation, la composition de bésilate de cisatracurium étant composée des composants suivants en poids : 13 à 18 g de bésilate de cisatracurium; 25 à 30 g d'un acide aminé; 3 à 5 g de carbone activé pour des aiguilles; 100 à 300 g de polyvinylpyrrolidone; une quantité appropriée d'un agent de réglage de pH; et ajouter de l'eau pour une injection à 2000 ml. La présente invention réduit le rapport d'échantillon atrophique de la composition de bésilate de cisatracurium, augmente le taux de qualification d'un produit, et réduit les coûts de production.
(ZH)
本发明公开了一种苯磺顺阿曲库铵组合物及其制备方法,所述的苯磺顺阿曲库铵组合物由下列组份按照重量组成:苯磺顺阿曲库铵13-18g;氨基酸25-30g;针用活性炭3-5g;聚乙烯吡咯烷酮100-300g;pH调节剂适量;注射用水加至2000ml。本发明降低了苯磺顺阿曲库铵组合物的萎缩样比例,提供产品的合格率,降低了生产成本。
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Latest bibliographic data on file with the International Bureau