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1. (WO2019047109) BIOINFORMATICS ANALYSIS METHOD AND SYSTEM FOR HPV PRECISE TYPING
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Pub. No.: WO/2019/047109 International Application No.: PCT/CN2017/100927
Publication Date: 14.03.2019 International Filing Date: 07.09.2017
IPC:
C12Q 1/70 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
深圳华大基因股份有限公司 BGI GENOMICS CO., LTD. [CN/CN]; 中国广东省深圳市 盐田区洪安三街21号华大综合园7栋7层-14层 Floors 7-14 Building No.7, BGI Park, No.21 Hongan 3rd Street, Yantian District Shenzhen, Guangdong 518083, CN
Inventors:
柴相花 CHAI, Xianghua; CN
王书元 WANG, Shuyuan; CN
刘强 LIU, Qiang; CN
袁玉英 YUAN, Yuying; CN
张红云 ZHANG, Hongyun; CN
刘娜 LIU, Na; CN
尹烨 YIN, Ye; CN
Agent:
北京品源专利代理有限公司 BEYOND ATTORNEYS AT LAW; 中国北京市 海淀区莲花池东路39号西金大厦6层 F6, Xijin Centre 39 Lianhuachi East Rd., Haidian District Beijing 100036, CN
Priority Data:
Title (EN) BIOINFORMATICS ANALYSIS METHOD AND SYSTEM FOR HPV PRECISE TYPING
(FR) MÉTHODE ET SYSTÈME D'ANALYSE BIOINFORMATIQUE POUR LE TYPAGE PRÉCIS DU HPV
(ZH) 一种HPV精确分型的生物信息学分析方法及系统
Abstract:
(EN) Disclosed in the present invention are a bioinformatics analysis method and system for HPV precise typing. The method comprises: receiving sequencing fragments obtained through high-throughput sequencing technology to obtain a reads sequence of each sample; grouping and clustering the reads sequences of all samples, comparing and screening the clustered reads sequences with HPV reference sequences, and determining the matching results of the screened reads sequences; and carrying out HPV typing on the reads sequences of determined HPV types by using an LDA model and finally determining the HPV type of each reads sequence.
(FR) La présente invention concerne une méthode et un système pour le typage précis du HPV. La méthode comprend : la réception de fragments de séquençage obtenus par une technologie de séquençage à haut débit pour obtenir une séquence de lecture de chaque échantillon ; le groupement et le regroupement des séquences de lecture de tous les échantillons, la comparaison et le criblage des séquences de lectures regroupées avec des séquences de référence du HPV, et la détermination des résultats de mise en correspondance des séquences de lectures criblées ; et la réalisation d'un typage du HPV sur les séquences de lectures des types de HPV déterminés à l'aide d'un modèle LDA et enfin la détermination du type de HPV de chaque séquence de lectures.
(ZH) 本发明公开了一种HPV精确分型的生物信息学分型方法及系统,所述方法包括:接收高通量测序技术得到的测序片段,得到每个样本的reads序列;将所有样本的reads序列进行分组聚类,将聚类后的reads序列与HPV参考序列集进行比对和筛选,确定筛选后的reads序列的匹配结果;对确定HPV型别的reads序列采用LDA模型进行HPV分型,最终确认每个reads序列的HPV型别。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)