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1. (WO2019047094) CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS
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Pub. No.: WO/2019/047094 International Application No.: PCT/CN2017/100858
Publication Date: 14.03.2019 International Filing Date: 07.09.2017
IPC:
C07D 401/14 (2006.01) ,A61K 31/4439 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
4427
containing further heterocyclic ring systems
4439
containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285, US
LILLY CHINA RESEARCH AND DEVELOPMENT CO., LTD. [CN/CN]; 780 Cailun Road, Rm. 819 Zhangjiang High Technology Park Pudong New Area Shanghai 201203, CN (MG)
Inventors:
LIU, Lian Zhu; US
ZHANG, Haizhen; US
WANG, Ziaoqing; US
LIU, Gang; US
Agent:
CHINA PATENT AGENT (H.K.) LTD.; 22/F., Great Eagle Center 23 Harbour Road, Wanchai Hong Kong, CN
Priority Data:
Title (EN) CYCLOBUTYL-IMIDAZOLIDINONE COMPOUNDS
(FR) COMPOSÉS DE CYCLOBUTYLE-IMIDAZOLIDINONE
Abstract:
(EN) A compound of the formula (I) wherein Q is selected from the group consisting of -C(CH 3) 2and (II); R is selected from the group consisting of (III) and (IV); or a pharmaceutically acceptable salt thereof; compositions, methods to treat liver disease and NASH.
(FR) La présente invention concerne un composé de formule (I) dans laquelle Q est choisi dans le groupe constitué par -C(CH 3) 2 et (II) ; R est choisi dans le groupe constitué par (III) et (IV) ; ou un sel pharmaceutiquement acceptable de celui-ci ; des compositions, des méthodes de traitement d'une maladie hépatique et d'une NASH.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)