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1. (WO2019046964) SIGNAL AMPLIFICATION SANDWICH FOR BIOANALYTE SIGNAL AMPLIFICATION AND DETECTION WITH ARTIFICIAL INTELLIGENCE DIAGNOSIS
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/046964 International Application No.: PCT/CA2018/051103
Publication Date: 14.03.2019 International Filing Date: 07.09.2018
Chapter 2 Demand Filed: 28.01.2019
IPC:
G01N 27/327 (2006.01) ,C12M 1/34 (2006.01) ,C12Q 1/68 (2018.01) ,C40B 70/00 (2006.01) ,G01N 27/416 (2006.01) ,G16H 50/20 (2018.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
28
Electrolytic cell components
30
Electrodes, e.g. test electrodes; Half-cells
327
Biochemical electrodes
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
34
Measuring or testing with condition measuring or sensing means, e.g. colony counters
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
70
Tags or labels specially adapted for combinatorial chemistry or libraries, e.g. fluorescent tags or bar codes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26
by investigating electrochemical variables; by using electrolysis or electrophoresis
416
Systems
[IPC code unknown for G16H 50/20]
Applicants:
GORDON, Neil [CA/CA]; CA
Inventors:
GORDON, Neil; CA
Priority Data:
62/556,35009.09.2017US
Title (EN) SIGNAL AMPLIFICATION SANDWICH FOR BIOANALYTE SIGNAL AMPLIFICATION AND DETECTION WITH ARTIFICIAL INTELLIGENCE DIAGNOSIS
(FR) SANDWICH D’AMPLIFICATION DE SIGNAL POUR AMPLIFICATION ET DÉTECTION DE SIGNAL DE BIOANALYTE AVEC DIAGNOSTIC PAR INTELLIGENCE ARTIFICIELLE
Abstract:
(EN) This invention discloses a signal amplification sandwich structure for amplifying detection signals from proteins, nucleic acids and microbes using a plurality of an electrochemically detectable oligonucleotide tag bound to a multifunctional particle. The invention further discloses a method and device that uses the signal amplification sandwich structure to detect and/or quantify low levels of one or more biological analytes using an off-the-shelf point-of-care electrochemical potentiostat, like a glucose meter for virtually any biological analyte. The invention further discloses a method and device that applies an artificial intelligence (AI) system to recommend actions for assessment and diagnosis of a disease, outbreak or condition with an artificial intelligence learning system to incorporate improvements, additions and modifications to the artificial intelligence systems and its constituents.
(FR) La présente invention concerne une structure de sandwich d’amplification de signal pour amplifier des signaux de détection de protéines, d’acides nucléiques et de microbes au moyen d’une pluralité d’étiquettes oligonucléotidiques électrochimiquement détectables liée à une particule multifonctionnelle. L’invention concerne en outre un procédé et un dispositif qui utilisent la structure sandwich d’amplification de signal pour détecter et/ou quantifier des taux faibles d’un ou plusieurs analytes biologiques au moyen un potentiostat électrochimique de point d’intervention commercial standard, tel qu’un glucomètre pour pratiquement n’importe quel analyte biologique. L’invention concerne en outre un procédé et un dispositif qui appliquent un système d’intelligence artificielle (AI) pour recommander des actions pour l’évaluation et le diagnostic d’une maladie, d’une poussée ou d’une affection avec un système d’apprentissage d’intelligence artificielle pour incorporer des améliorations, des ajouts et des modifications aux systèmes d’intelligence artificielle et à leurs constituants.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)