Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019046896) METHODS AND MARKERS FOR ASSESSING CANCER PROGRESSION
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/046896 International Application No.: PCT/AU2018/050966
Publication Date: 14.03.2019 International Filing Date: 06.09.2018
IPC:
G01N 33/574 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
UNIVERSITY OF SOUTH AUSTRALIA [AU/AU]; North Terrace Adelaide, South Australia 5000, AU
CENTRAL ADELAIDE LOCAL HEALTH NETWORK INC. [AU/AU]; North Terrace Adelaide, South Australia 5000, AU
MONASH UNIVERSITY [AU/AU]; Wellington Road Clayton, Victoria 3800, AU
Inventors:
KHEW-GOODALL, Yeesim; AU
BELLE, Leila; AU
IONIC, Ana; AU
DALY, Roger; AU
Agent:
PHILLIPS ORMONDE FITZPATRICK; Level 16 333 Collins Street Melbourne, Victoria 3000, AU
Priority Data:
201790361206.09.2017AU
Title (EN) METHODS AND MARKERS FOR ASSESSING CANCER PROGRESSION
(FR) PROCÉDÉS ET MARQUEURS POUR ÉVALUER LA PROGRESSION D'UN CANCER
Abstract:
(EN) The present disclosure relates to methods and markers for assessing cancer progression. In certain embodiments, the present disclosure provides a method of assessing progression of a cancer disease associated with increased or undesired receptor tyrosine kinase activity, the method comprising assessing endosomal recycling of the receptor tyrosine kinase mediated by phosphorylated PKCΔ associated with the cancer disease, wherein increased endosomal recycling of the receptor tyrosine kinase is indicative of progression of the cancer disease from a less progressed stage to a more progressed stage.
(FR) La présente invention concerne des procédés et des marqueurs pour détecter la progression d'un cancer. Dans certains modes de réalisation, la présente invention concerne un procédé d'évaluation de la progression d'une maladie cancéreuse associée à une activité de récepteur de tyrosine kinase accrue ou indésirable, le procédé comprenant l'évaluation du recyclage endosomal du récepteur de la tyrosine kinase par médiation de la PKCΔ phosphorylée associée à la maladie cancéreuse, le recyclage endosomal accru du récepteur de la tyrosine kinase étant indicatif de la progression de la maladie cancéreuse d'un stade moins avancé à un stade plus avancé.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)