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1. (WO2019046856) T CELL RECEPTORS THAT BIND TO MIXED LINEAGE LEUKEMIA (MLL)-SPECIFIC PHOSPHOPEPTIDES AND METHODS OF USE THEREOF
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Pub. No.: WO/2019/046856 International Application No.: PCT/US2018/049397
Publication Date: 07.03.2019 International Filing Date: 04.09.2018
IPC:
C07K 14/705 (2006.01) ,C07K 14/47 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
Applicants:
AGENUS INC. [US/US]; 3 Forbes Road Lexington, MA 02421, US
Inventors:
VAN DIJK, Marc; NL
BREOUS-NYSTROM, Ekaterina Vladimirovna; CH
FRANCHINO, Alessandra; CH
LALEVÉE, Sébastien; FR
HURWITZ, Arthur Andrew; US
EXLEY, Mark Adrian; US
WOLF, Benjamin Jacob; US
Agent:
WILKINS, Andrew T.; US
COUGHLIN, Sean M.; US
ANIS, Hissan; US
BARTON, Steven K.; US
CHEN, Xiaoyue (Peter); US
CUSTER, Andrew W.; US
DECONTI, Giulio A.; US
DELANEY, Marie; US
DIZEREGA, Philip; US
LAMBRECHTS, Robert J.; US
LINK, Douglas; US
MORIARITY, Gordon R.; US
POPLIN, Alan J.; US
QUINN, Anna; US
SPELLBERG, Michael; US
STEELE, Alan; US
STONE-HULSLANDER, Judith; US
TEOFILO, Javier; US
TRINQUE, Brian C.; US
VELEMA, James H.; US
VOCK, Curtis A.; US
Priority Data:
62/553,95704.09.2017US
Title (EN) T CELL RECEPTORS THAT BIND TO MIXED LINEAGE LEUKEMIA (MLL)-SPECIFIC PHOSPHOPEPTIDES AND METHODS OF USE THEREOF
(FR) RÉCEPTEURS DE LYMPHOCYTES T QUI SE LIENT À DES PHOSPHOPEPTIDES SPÉCIFIQUES DE LA LEUCÉMIE DE LIGNÉE MIXTE (MLL) ET MÉTHODES D'UTILISATION DE CES DERNIERS
Abstract:
(EN) Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.
(FR) L'invention concerne des TCR (par exemple, des TCR qui se lient à MLL, par exemple des TCR qui se lient à un phosphopeptide MLL, par exemple des TCR qui se lient à un complexe MHC/phosphopeptide MLL), des cellules et des compositions pharmaceutiques comprenant ces TCR, des acides nucléiques codant pour ces TCR, des vecteurs d'expression et des cellules hôtes pour la préparation de ces TCR, et des méthodes de traitement d'un sujet à l'aide de ces TCR.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)