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1. (WO2019046826) METHODS FOR QUANTIFYING LIGAND EFFICACY IN G-PROTEIN COUPLED RECEPTORS USING SINGLE-MOLECULE FLUORESENCE ENERGY TRANSFER
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Pub. No.: WO/2019/046826 International Application No.: PCT/US2018/049275
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07K 14/435 (2006.01) ,C07K 14/705 (2006.01) ,C07K 14/72 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
72
for hormones
Applicants:
CORNELL UNIVERSITY [US/US]; Center for Technology Licensing 395 Pine Tree Road, Suite 310 Ithaca, New York 14850, US
Inventors:
BLANCHARD, Scott C.; US
GREGORIO, Gabriel Glenn; US
KOBILKA, Brian; US
Agent:
EWING, James F.; US
MCPARLAND, James P.; US
MEARA, Joseph P.; US
HAYS, Rebecca L.; US
Priority Data:
62/553,70801.09.2017US
Title (EN) METHODS FOR QUANTIFYING LIGAND EFFICACY IN G-PROTEIN COUPLED RECEPTORS USING SINGLE-MOLECULE FLUORESENCE ENERGY TRANSFER
(FR) PROCÉDÉS DE QUANTIFICATION DE L'EFFICACITÉ D'UN LIGAND DANS DES RÉCEPTEURS COUPLÉS À LA PROTÉINE G AU MOYEN D'UN TRANSFERT D'ÉNERGIE PAR FLUORESCENCE À MOLÉCULE UNIQUE
Abstract:
(EN) Disclosed herein are methods for providing a molecular efficacy of a ligand, especially when utilizing single-molecule fluorescence resonance energy transfer ("smFRET") imaging, as well as compounds useful in such methods.
(FR) L'invention concerne des procédés pour fournir une efficacité moléculaire d'un ligand, en particulier lors de l'utilisation d'une imagerie à transfert d'énergie par résonance fluorescente par molécule unique ("smFRET"), ainsi que des composés utiles dans de tels procédés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)