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1. (WO2019046815) TRANSPOSON SYSTEM AND METHODS OF USE
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Pub. No.: WO/2019/046815 International Application No.: PCT/US2018/049257
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C12N 15/90 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
87
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
90
Stable introduction of foreign DNA into chromosome
Applicants:
SHEDLOCK, Devon [US/US]; US
HERMANSON, David [US/US]; US
OSTERTAG, Eric [US/US]; US
RICHTER, Maximilian [US/US]; US
CRANERT, Stacey Ann [US/US]; US
POSEIDA THERAPEUTICS, INC. [US/US]; 4242 Campus Point Court, Suite 700 San Diego, California 92121, US
Inventors:
SHEDLOCK, Devon; US
HERMANSON, David; US
OSTERTAG, Eric; US
RICHTER, Maximilian; US
CRANERT, Stacey Ann; US
Agent:
MILLER, Katherine J.; US
ELRIFI, Ivor R.; US
Priority Data:
62/552,86131.08.2017US
62/558,28613.09.2017US
62/608,54620.12.2017US
Title (EN) TRANSPOSON SYSTEM AND METHODS OF USE
(FR) SYSTÈME DE TRANSPOSON ET PROCÉDÉS D'UTILISATION
Abstract:
(EN) Disclosed are methods for the ex-vivo genetic modification of an immune cell comprising delivering to the immune cell, (a) a nucleic acid or amino acid sequence comprising a sequence encoding a transposase enzyme and (b) a recombinant and nonnaturally occurring DNA sequence comprising a DNA sequence encoding a transposon.
(FR) L'invention concerne des procédés de modification génétique ex-vivo d'une cellule immunitaire consistant à administrer à la cellule immunitaire, (a) une séquence d'acide aminé ou d'acide nucléique comprenant une séquence codant pour une enzyme transposase et (b) une séquence d'ADN non naturelle et recombinante comprenant une séquence d’ADN codant pour un transposon.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)