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1. (WO2019046807) PHENOTYPIC PROFILING OF HEPATOCELLULAR CARCINOMA CIRCULATING TUMOR CELLS FOR TREATMENT SELECTION
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Pub. No.: WO/2019/046807 International Application No.: PCT/US2018/049249
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07K 16/28 (2006.01) ,C07K 16/30 (2006.01) ,G01N 33/574 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
30
from tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Twelfth Floor Oakland, California 94607-5200, US
Inventors:
AGOPIAN, Vatche; US
TSENG, Hsian-Rong; US
HOU, Shuang; US
Agent:
CANADY, Karen S.; US
HYMAN, Laurence J.; US
SUNDBY, Suzannah K.; US
LORTZ, Bradley K.; US
Priority Data:
62/553,74201.09.2017US
Title (EN) PHENOTYPIC PROFILING OF HEPATOCELLULAR CARCINOMA CIRCULATING TUMOR CELLS FOR TREATMENT SELECTION
(FR) PROFILAGE PHÉNOTYPIQUE DE CELLULES TUMORALES CIRCULANTES D'UN CARCINOME HÉPATOCELLULAIRE POUR LA SÉLECTION D'UN TRAITEMENT
Abstract:
(EN) Methods and kits for detecting hepatocellular carcinoma recurrence or metastasis, and of measuring markers of hepatocellular carcinoma, including markers of hepatocellular carcinoma recurrence or metastasis, in a blood sample obtained from a subject by (a) isolating circulating tumor cells (CTCs) by contacting a blood sample obtained from the subject with a set of capture antibodies, wherein the capture antibodies specifically bind asialoglycoprotein receptor (ASGPR), Glypican-3, and epithelial cell adhesion molecule (EpCAM); (b) contacting the isolated CTCs with an antibody that specifically binds vimentin; and (c) measuring the number of vimentin-positive CTC.
(FR) L'invention concerne des méthodes et des kits pour la détection d'une récidive ou de métastases d'un carcinome hépatocellulaire, et de mesure de marqueurs d'un carcinome hépatocellulaire, notamment des marqueurs d'une récidive ou de métastases d'un carcinome hépatocellulaire, dans un échantillon de sang obtenu d'un sujet par (a) l'isolement des cellules tumorales circulantes (CTC) par la mise en contact d'un échantillon de sang obtenu du sujet avec un ensemble d'anticorps de capture, les anticorps de capture se liant spécifiquement au récepteur d'asialoglycoprotéine (ASGPR), le glypicane-3, et à la molécule d'adhésion des cellules épithéliales (EpCAM) ; (b) la mise en contact des CTC isolées avec un anticorps qui se lie spécifiquement à la vimentine ; et (c) la mesure du nombre de CTC positives à la vimentine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)