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1. (WO2019046801) MOLECULAR BACTERIOTHERAPY TO CONTROL SKIN ENZYMATIC ACTIVITY
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Pub. No.: WO/2019/046801 International Application No.: PCT/US2018/049237
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
A61K 35/741 (2015.01) ,A61K 38/04 (2006.01) ,A61K 38/08 (2006.01) ,A61K 38/16 (2006.01) ,C07K 7/06 (2006.01) ,C07K 14/31 (2006.01)
[IPC code unknown for A61K 35/741]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
305
from Micrococcaceae (F)
31
from Staphylococcus (G)
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 5th Floor Oakland, CA 94607-5200, US
Inventors:
GALLO, Richard, L.; US
WILLIAMS, Michael; US
Agent:
BAKER, Joseph, R., Jr.; US
Priority Data:
62/553,02531.08.2017US
Title (EN) MOLECULAR BACTERIOTHERAPY TO CONTROL SKIN ENZYMATIC ACTIVITY
(FR) BACTÉRIOTHÉRAPIE MOLÉCULAIRE POUR CONTRÔLER L'ACTIVITÉ ENZYMATIQUE DE LA PEAU
Abstract:
(EN) The invention provides a purified polypeptide which inhibits (i) protease production and/or activity of keratinocytes, (ii) inhibits IL-6 production and/or activity of keratinocytes, (iii) inhibits production of phenol soluble modulin alpha 3 from Staphylococcus aureus and/or (iv) inhibits agr production and/or activity by S. aureus. Further provided is a topical formulation comprising the polypeptide. Provided is a recombinant microorganism comprising a vector or polynucleotide encoding the polypeptide. Further provided is a probiotic composition comprising the recombinant microorganism. The invention also provides kits and articles of manufacture comprising the polypeptide and/or the recombinant microorganism.
(FR) L'invention concerne un polypeptide purifié qui inhibe (i) la production et/ou l'activité de protéase des kératinocytes, (ii) inhibe la production et/ou l'activité de l'IL -6 des kératinocytes, (iii) inhibe la production de la moduline alpha 3 soluble dans le phénol à partir de Staphylococcus aureus et/ou (iv) inhibe la production et/ou l'activité de agr par S. aureus. L'invention concerne en outre une formulation topique comprenant le polypeptide. L'invention concerne un micro-organisme recombinant comprenant un vecteur ou un polynucléotide codant pour le polypeptide. L'invention concerne en outre une composition probiotique comprenant le micro-organisme recombinant. L'invention concerne également des kits et des articles manufacturés comprenant le polypeptide et/ou le micro-organisme recombinant.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)