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1. (WO2019046795) VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS
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Pub. No.: WO/2019/046795 International Application No.: PCT/US2018/049225
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07D 401/14 (2006.01) ,C07D 403/06 (2006.01) ,C07D 403/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
Applicants:
ANGION BIOMEDICA CORP. [US/US]; 51 Charles Lindbergh Blvd. Uniondale, New York 11553, US
Inventors:
LI, An-Hu; US
DANA, Dibyendu; US
LIM, Dong Sung; US
GADHIYA, Satishkumar; US
JUNG, Dawoon; US
NARAYAN, Prakash; US
ALI, Quaisar; US
PAKA, Latha; US
GOLDBERG, Itzhak D.; US
Agent:
COHEN, Mark; US
PEARL COHEN ZEDEK LATZER BARATZ LLP; 1500 Broadway, 12th Floor New York, New York 10036, US
Priority Data:
62/553,88503.09.2017US
Title (EN) VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS
(FR) HÉTÉROCYCLES VINYLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE LA KINASE BISPIRALÉE ASSOCIÉE À RHO (ROCK)
Abstract:
(EN) The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R1, R2, R3, A1, and A2 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.
(FR) La présente invention concerne des composés ayant la formule (I) : et des sels de qualité pharmaceutique de ceux-ci. Dans la formule, Cy1, Cy2, Cy3, R, R1, R2, R3, A1 et A2 sont tels que décrits généralement et dans les catégories et sous-catégories de la description. L'invention concerne en outre des compositions pharmaceutiques à base de ceux-ci et des procédés pour leur utilisation en vue du traitement de l'une quelconque parmi un certain nombre d'affections ou de maladies dans lesquelles l'inhibition de ROCK1, ROCK2 ou ROCK1/2 joue un rôle thérapeutiquement utile.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)