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1. WO2019046795 - VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS

Publication Number WO/2019/046795
Publication Date 07.03.2019
International Application No. PCT/US2018/049225
International Filing Date 31.08.2018
IPC
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 403/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14containing three or more hetero rings
CPC
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
14containing three or more hetero rings
Applicants
  • ANGION BIOMEDICA CORP. [US]/[US]
Inventors
  • LI, An-Hu
  • DANA, Dibyendu
  • LIM, Dong Sung
  • GADHIYA, Satishkumar
  • JUNG, Dawoon
  • NARAYAN, Prakash
  • ALI, Quaisar
  • PAKA, Latha
  • GOLDBERG, Itzhak D.
Agents
  • COHEN, Mark
  • PEARL COHEN ZEDEK LATZER BARATZ LLP
Priority Data
62/553,88503.09.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VINYLHETEROCYCLES AS RHO-ASSOCIATED COILED-COIL KINASE (ROCK) INHIBITORS
(FR) HÉTÉROCYCLES VINYLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE LA KINASE BISPIRALÉE ASSOCIÉE À RHO (ROCK)
Abstract
(EN)
The present invention provides compounds having formula (I): and pharmaceutically acceptable salts thereof, wherein Cy1, Cy2, Cy3, R, R1, R2, R3, A1, and A2 are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which inhibiting ROCK1, ROCK2, or ROCK1/2 has a therapeutically useful role.
(FR)
La présente invention concerne des composés ayant la formule (I) : et des sels de qualité pharmaceutique de ceux-ci. Dans la formule, Cy1, Cy2, Cy3, R, R1, R2, R3, A1 et A2 sont tels que décrits généralement et dans les catégories et sous-catégories de la description. L'invention concerne en outre des compositions pharmaceutiques à base de ceux-ci et des procédés pour leur utilisation en vue du traitement de l'une quelconque parmi un certain nombre d'affections ou de maladies dans lesquelles l'inhibition de ROCK1, ROCK2 ou ROCK1/2 joue un rôle thérapeutiquement utile.
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