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1. (WO2019046761) THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING SAME
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Pub. No.: WO/2019/046761 International Application No.: PCT/US2018/049163
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07F 1/08 (2006.01) ,A61P 25/14 (2006.01) ,A61K 33/34 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
1
Compounds containing elements of the 1st Group of the Periodic System
08
Copper compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33
Medicinal preparations containing inorganic active ingredients
24
Heavy metals; Compounds thereof
34
Copper; Compounds thereof
Applicants:
OREGON STATE UNIVERSITY [US/US]; Office For Commercialization & Corporate Development A312 Kerr Administration Building Corvallis, OR 97331-2140, US
Inventors:
BEAUDRY, Chris; US
HURST, James; US
BECKMAN, Joseph; US
SIROIS, John; US
Agent:
SCHWARTZ, Johanna P.; US
Priority Data:
62/553,71401.09.2017US
Title (EN) THERAPEUTIC METAL COMPLEXES AND LIGANDS AND METHODS OF MAKING AND USING SAME
(FR) COMPLEXES DE MÉTAL THÉRAPEUTIQUES ET LIGANDS, LEURS PROCÉDÉS DE FABRICATION ET D'UTILISATION
Abstract:
(EN) Disclosed herein are compound embodiments that are useful for treating a variety of diseases, particularly neurological diseases, motor neuron diseases, copper deficiency-related diseases, and/or mitochondrial deficiencies. The compound embodiments described herein also can be used in PET methods. Also disclosed herein are embodiments of methods of making and using the compound embodiments, as well as pharmaceutical formulations comprising the disclosed compound embodiments.
(FR) L'invention concerne des modes de réalisation de composés qui sont utiles pour traiter diverses maladies, en particulier des maladies neurologiques, des maladies de motoneurones, des maladies associées à une déficience en cuivre et/ou des déficiences mitochondriales. Les modes de réalisation de composés selon la présente invention peuvent également être utilisés dans des procédés PET. L'invention concerne également des modes de réalisation de procédés de fabrication et d'utilisation des modes de réalisation de composés, ainsi que des formulations pharmaceutiques comprenant les modes de réalisation de composés selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)