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1. (WO2019046668) AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS
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Pub. No.: WO/2019/046668 International Application No.: PCT/US2018/048997
Publication Date: 07.03.2019 International Filing Date: 31.08.2018
IPC:
C07D 417/12 (2006.01) ,C07D 277/46 (2006.01) ,A61K 31/426 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
277
Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02
not condensed with other rings
20
having two or three double bonds between ring members or between ring members and non-ring members
32
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
44
Acylated amino or imino radicals
46
by carboxylic acids, or sulfur or nitrogen analogues thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
426
1,3-Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
KEZAR LIFE SCIENCES [US/US]; 4000 Shoreline Court Ste. 300 South San Francisco, CA 94080, US
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 12th Floor Oakland, CA 94607-5200, US
Inventors:
MCMINN, Dustin; US
JOHNSON, Henry; US
TAUNTON, John, William; US
CARRASCO, Yazmin, Paulina; US
SHARP, Phillip, Patrick; US
Agent:
DANEK, Shelley, C.; US
Priority Data:
62/552,85731.08.2017US
Title (EN) AMIDE SUBSTITUTED THIAZOLES AS PROTEIN SECRETION INHIBITORS
(FR) THIAZOLES À SUBSTITUTION AMIDE UTILISÉS EN TANT QU'INHIBITEURS DE LA SÉCRÉTINE PROTÉIQUE
Abstract:
(EN) Provided herein are thiazole carboxamide protein secretin inhibitors, such as inhibitors of Sec61, methods for their preparation, related pharmaceutical compositions, and methods for using the same. For example, provided herein are compounds of Formula (I): and pharmaceutically acceptable salts and compositions including the same. The compounds disclosed herein may be used, for example, in the treatment of diseases including inflammation and/or cancer.
(FR) L'invention concerne des inhibiteurs de la sécrétine protéique de carboxamide de thiazole, tels que des inhibiteurs de Sec61, leurs procédés de préparation, des compositions pharmaceutiques apparentées, et leurs procédés d'utilisation. Par exemple, l'invention concerne des composés de formule (I) : et des sels pharmaceutiquement acceptables et des compositions les comprenant. Les composés et les compositions selon l'invention peuvent être utilisés, par exemple, dans le traitement de maladies comprenant l'inflammation et/ou le cancer.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)