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1. (WO2019046652) ACTIVATABLE ANTI-CD166 ANTIBODIES AND METHODS OF USE THEREOF
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Pub. No.: WO/2019/046652 International Application No.: PCT/US2018/048965
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C07K 16/28 (2006.01) ,A61K 47/68 (2017.01) ,A61P 35/00 (2006.01) ,A61K 47/65 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
28
against receptors, cell surface antigens or cell surface determinants
[IPC code unknown for A61K 47/68]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
[IPC code unknown for A61K 47/65]
Applicants:
CYTOMX THERAPEUTICS, INC. [US/US]; 151 Oyster Point Blvd. Suite 400 South San Francisco, California 94080, US
Inventors:
CARMAN, Lori; US
HUMPHREY, Rachel; US
KAVANAUGH, W. Michael; US
TERRETT, Jonathan; US
WEAVER, Annie Yang; US
WILL, Matthias; US
Agent:
ELRIFI, Ivor R.; US
KOZAKIEWICZ, Cynthia A.; US
ROY, Madhuri; US
Priority Data:
62/552,34530.08.2017US
62/553,09831.08.2017US
62/554,91906.09.2017US
Title (EN) ACTIVATABLE ANTI-CD166 ANTIBODIES AND METHODS OF USE THEREOF
(FR) ANTICORPS ANTI-CD166 ACTIVABLES, ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Provided herein are activatable antibodies that specifically bind to CD166 and conjugated activatable antibodies that specifically bind to CD166. Also provided are methods of making and using these activatable antibodies in a variety of therapeutic, diagnostic and prophylactic indications.
(FR) L'invention concerne des anticorps activables qui se lient de manière spécifique à CD166 et des anticorps activables conjugués qui se lient de manière spécifique à CD166. L'invention concerne également des procédés de fabrication et d'utilisation de ces anticorps activables dans diverses indications thérapeutiques, diagnostiques et prophylactiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)