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1. (WO2019046619) TP53 AS BIOMARKER FOR RESPONSIVENESS TO IMMUNOTHERAPY
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Pub. No.: WO/2019/046619 International Application No.: PCT/US2018/048916
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
A61K 39/395 (2006.01) ,A61P 35/00 (2006.01) ,C12N 5/0783 (2010.01) ,C12Q 1/68 (2018.01) ,C12Q 1/6813 (2018.01) ,C12Q 1/6827 (2018.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
[IPC code unknown for C12Q 1/6813][IPC code unknown for C12Q 1/6827]
Applicants:
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE [US/US]; 10901 N. Torrey Pines Road La Jolla, California 92037, US
Inventors:
WECHSLER-REYA, Robert; US
GARANCHER, Alexandra; US
WARE, Carl; US
Agent:
LIN, Clark Y.; US
Priority Data:
62/552,22130.08.2017US
62/702,80224.07.2018US
Title (EN) TP53 AS BIOMARKER FOR RESPONSIVENESS TO IMMUNOTHERAPY
(FR) GÈNE TP53 UTILISÉ EN TANT QUE BIOMARQUEUR POUR LA RÉACTIVITÉ À UNE IMMUNOTHÉRAPIE
Abstract:
(EN) Disclosed herein are methods of treating a subject by an immunotherapy in combination with a low-dose of TNF-a or an LT receptor agonist as well as methods of identifying a cancer patient as having an increased or a reduced likelihood of responding to an immunotherapy by detection of TP53 gene status, in isolation, or in combination with assays for determining the levels of MHC-I and TP53 target genes. Also provided are methods of administering an immunotherapy to select, identified cancer patients.
(FR) L'invention concerne des méthodes de traitement d'un sujet par une immunothérapie en combinaison avec une faible dose de TNF-a ou d'un agoniste du récepteur aux LT, ainsi que des procédés d'identification d'un patient cancéreux comme présentant une probabilité accrue ou réduite de répondre à une immunothérapie par détection du statut du gène TP53, isolément ou en combinaison avec des dosages permettant de déterminer les niveaux de gènes cibles TP53 et du CMH-I. L'invention concerne également des procédés d'administration d'une immunothérapie à des patients cancéreux identifiés et sélectionnés.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)