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1. (WO2019046593) COMPACT AUTO-INJECTOR
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CLAIMS

What is claimed is:

1. A compact, high aspect ratio auto-injector for delivering a medicament dose subcutaneously or intramuscularly, the auto-injector comprising:

a housing;

a medicament dispensing system disposed within the housing and comprising a medicament reservoir adapted to contain the dose; and

a needle extension mechanism coupled to the medicament reservoir, the needle extension mechanism comprising a curved injection needle adapted to be straightened during deployment of the needle to facilitate dispensing of the dose by the auto-injector.

2. The auto-injector according to claim 1, wherein the housing comprises a sealed housing rotatably retained in a cover.

3. The auto-injector according to claim 2, where the housing further comprises an interface to receive user input to facilitate a manual rotation of the housing relative to the cover from a first locked position to a second unlocked position.

4. The auto-injector according to claim 3, wherein at least one of the housing, the cover, a label, and a component directly visible to the user comprises indicia indicating the locked position, the unlocked position, and an armed position.

5. The auto-injector according to claim 3, wherein the auto-injector further comprises a biasing member, such that when the housing is rotated to the unlocked position, the sealed housing is automatically displaced axially relative to the cover, increasing a height of the auto-injector.

6. The auto-injector according to claim 5, wherein the biasing member comprises a spring that is at least one of integrally formed with the housing integrally formed with the cover, and disposed between the housing and the cover.

7. The auto-injector according to claim 5, wherein the auto-injector further comprises an interlock, such that the housing cannot be rotated relative to the cover or displaced axially relative to the cover without removal of the interlock.

8. The auto-injector according to claim 5, wherein manual compression of the auto-injector in an armed position, reduces the height of the auto-injector, and activates a mechanism that straightens and extends a distal end of the injection needle through the housing, dispenses the dose through the injection needle, and activates an interlock.

9. The auto-injector according to claim 8, wherein upon release of manual compression, the biasing member automatically displaces the housing axially relatively to the cover, increasing a height of the auto-injector and retracting the distal end of the injection needle into the housing.

10. The auto-injector according to claim 9, wherein the auto-injector further comprises an interlock to prevent subsequent manual compression of the auto-injector, thereby rendering the auto-injector single-use.

11. The auto-injector according to claim 10, wherein the interlock comprises an abutting structure in the housing and the cover.

12. The auto-injector according to claim 1, wherein the medicament dispensing system further comprises a plunger within the medicament reservoir and forming a sealed cavity for retaining the dose.

13. The auto-injector according to claim 12, wherein the medicament dispensing system further comprises a dispensing needle in fluidic communication with the injection needle.

14. The auto-injector according to claim 13, further comprising a flexible tube interconnecting the dispensing needle with the injection needle.

15. The auto-injector according to claim 13, wherein the medicament dispensing system further comprises a spring, a retainer, and a locking mechanism such that when the locking mechanism is released, the spring displaces the retainer and forces the dispensing needle to pierce the plunger to provide fluidic communication with the dose.

16. The auto-injector according to claim 15, wherein the cover comprises a second trigger to release the retainer and the locking mechanism.

17. The auto-injector according to claim 15, wherein the spring further displaces the plunger to pump the dose out of the vial and through the dispensing needle to the injection needle.

18. The auto-injector according to claim 15, wherein the spring comprises a compression spring.

19. The auto-injector according to claim 1, wherein the needle extension mechanism further comprises a needle barrel for supporting the curved injection needle, a spring coupled to the barrel for rotating the barrel to uncoil the curved injection needle, and a barrel locking mechanism to prevent inadvertent rotation of the barrel.

20. The auto-injector according to claim 19, wherein the spring comprises a torsion spring.

21. The auto-injector according to claim 19, wherein the cover forms an aperture through which a distal end of the injection needle passes during rotation of the barrel to straighten the injection needle.

22. The auto-injector according to claim 21, wherein release of the barrel locking mechanism permits the spring to rotate the barrel and deploy the injection needle.

23. The auto-injector according to claim 22, wherein the cover comprises a first trigger to release the needle barrel locking mechanism.

24. The auto-injector according to claim 19, wherein the needle extension mechanism further comprises a needle barrel cap to secure a proximal end of the injection needle to the needle barrel.

25. A method of operating a compact, high aspect ratio auto-injector for delivering a medicament dose subcutaneously or intramuscularly, the auto-injector comprising a housing, a medicament dispensing system comprising a medicament reservoir adapted to contain the dose, and a needle extension mechanism coupled to the medicament reservoir, the needle extension mechanism comprising a curved injection needle, the method comprising the steps of:

triggering deployment of a distal end of a curved injection needle through an aperture in a cover of the housing to straighten the injection needle;

triggering piercing of the medicament reservoir to provide fluidic communication between the reservoir and the curved injection needle;

dispensing the dose through the injection needle at a desired injection location; and thereafter, retracting the distal end of the injection needle into the auto-injector.

26. The method according to claim 25, wherein the auto-injector further comprises an interlock, such that the housing cannot be rotated relative to the cover or displaced axially relative to the cover without removal of the interlock.

27. The method according to claim 25, wherein the housing comprises a sealed housing rotatably retained in the cover, the method further comprising the steps of:

manually rotating the housing relative to the cover from a first locked position to a second unlocked position, in which the sealed housing is automatically displaced axially relative to the cover to an armed position, increasing a height of the auto-injector.

28. The method according to claim 27, further comprising the step of determining the locked position, the unlocked position, and the armed position based on indicia on at least one of the housing, the cover, a label, and a component directly visible to the user.

29. The method according to claim 27, further comprising the step of adhering the cover to the desired injection location prior to triggering of the auto-injector.

30. The method according to claim 25, wherein the step of triggering piercing of the medicament reservoir comprises manually compressing the auto-injector when the auto-injector is in the armed position, which comprises activating the medicament dispensing mechanism triggering piercing of a plunger within the medicament reservoir with a distal end of a dispensing needle.

31. The method according to claim 30, wherein the step of triggering piercing of the medicament reservoir further comprises pumping the dose out of the reservoir to the injection needle.

32. The method according to claim 30, where in the step of manually compressing the auto-injector when the auto-injector is in the armed position further comprises activating the needle extension mechanism triggering the deployment of the curved injection needle through the aperture in the cover.

33. The method according to claim 32, wherein the step of activating the needle extension mechanism comprising deploying the curved injection needle through the aperture in the cover further comprises rotating a needle barrel to drive the distal end of the curved injection needle through the aperture.

34. The method according to claim 32, wherein the step of activating the needle extension mechanism comprises deploying a distal end of the curved injection needle through the aperture in the cover to straighten the injection needle.

35. The method according to claim 25, wherein the step of retracting the distal end of the injection needle into the auto-injector results from releasing manual compression of the auto-injector.

36. The method according to claim 25, further comprising the step of removing the auto-injector from the desired injection location after dispensing the dose.

37. The method according to claim 25, further comprising the step of automatically interlocking the auto-injector after retraction of the needle to prevent reuse of the auto-injector and exposure of a distal end of the injection needle.

38. The method according to claim 25, further comprising the step of disposing of the auto-injector after a single use.