Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2019046585) GENE EXPRESSION SUBTYPE ANALYSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA FOR TREATMENT MANAGEMENT
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2019/046585 International Application No.: PCT/US2018/048862
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
GENECENTRIC THERAPEUTICS, INC. [US/US]; 79 TW Alexander Drive 4401 Research Commons, Suite 105 Research Triangle Park, North Carolina 27709, US
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 109 Church Street Chapel Hill, North Carolina 27516, US
Inventors:
LAI-GOLDMAN, Myla; US
FARUKI, Hawazin; US
MAYHEW, Greg; US
PEROU, Charles; US
HAYES, David Neil; US
ZEVALLOS, Jose; US
Agent:
MCEVOY, Michael T.; US
TUSCAN, Michael S.; US
WHITTLE, James R.R.; US
Priority Data:
62/552,00130.08.2017US
62/608,22020.12.2017US
Title (EN) GENE EXPRESSION SUBTYPE ANALYSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA FOR TREATMENT MANAGEMENT
(FR) ANALYSE DE SOUS-TYPES D'EXPRESSION GÉNIQUE DU CARCINOME ÉPIDERMOÏDE DE LA TÊTE ET DU COU POUR LA GESTION DU TRAITEMENT
Abstract:
(EN) Methods are provided for determining a subtype of head and neck squamous cell carcinoma (HNSCC) of an individual by detecting the expression level of at least one subtype classifier selected from a group of genes that are relevant for determining HNSCC subtypes. Also provided herein are methods for determining a suitable treatment and predicting the overall survival and the likelihood of metastasis for the HNSCC patients according to their subtypes.
(FR) L'invention concerne des procédés pour la détermination d'un sous-type du carcinome épidermoïde de la tête et du cou d'un sujet par détection du niveau d'expression d'au moins un classificateur de sous-type choisi dans un groupe de gènes pertinents pour la détermination des sous-types du carcinome épidermoïde de la tête et du cou. L'invention concerne également des procédés pour déterminer un traitement approprié et prédire la survie globale et la probabilité de métastases pour les patients souffrant d'un carcinome épidermoïde de la tête et du cou selon le sous-type.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)