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1. (WO2019046563) METHOD AND DEVICE OF USING AQUEOUS TWO-PHASE SYSTEMS (ATPS) FOR ENHANCING DIAGNOSTICS FOR SEXUALLY TRANSMITTED INFECTIONS
Latest bibliographic data on file with the International BureauSubmit observation

Pub. No.: WO/2019/046563 International Application No.: PCT/US2018/048822
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
G01N 33/483 (2006.01) ,G01N 33/543 (2006.01) ,G01N 33/558 (2006.01) ,G01N 33/569 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
558
using diffusion or migration of antigen or antibody
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
PHASE DIAGNOSTICS, INC. [US/US]; 10527 Garden Grove Blvd. Garden Grove, California 92843, US
Inventors:
CHIU, Yin To; US
MOSLEY, Garrett Lee; US
LEE, Brian Sangwoo; US
Agent:
WAI-KIT CHAN, Albert; US
Priority Data:
62/553,20701.09.2017US
Title (EN) METHOD AND DEVICE OF USING AQUEOUS TWO-PHASE SYSTEMS (ATPS) FOR ENHANCING DIAGNOSTICS FOR SEXUALLY TRANSMITTED INFECTIONS
(FR) PROCÉDÉ ET DISPOSITIF D'UTILISATION DE SYSTÈMES AQUEUX BIPHASES (ATPS) POUR AMÉLIORER LE DIAGNOSTIC DES INFECTIONS SEXUELLEMENT TRANSMISSIBLES
Abstract:
(EN) This invention relates to a method and device for improving the accuracy and performance of detecting or diagnosing sexually transmitted infections (STIs) or STI-causing pathogens. In one embodiment, the present method and device are related to removing one or more interfering molecules such as urea from urine sample, where these interfering molecules alter the performance of Lateral-Flow Immunoassay (LFA). In one embodiment, an aqueous two-phase system (ATPS) embedded entirely within a porous material allows spontaneous phase separation and the target STI-causing pathogens is concentrated in one of the separated phases. In one embodiment, a detection module such as the Lateral-Flow Immunoassay (LFA) is used in connection with other modules so as to detect or diagnose the sexually transmitted infections or the pathogens associated with STIs with an improved performance.
(FR) La présente invention concerne un procédé et un dispositif pour améliorer la précision et la performance de détection ou de diagnostic des infections sexuellement transmissibles (IST) ou des agents pathogènes provoquant une IST. Dans un mode de réalisation, les présents procédé et dispositif consistent à éliminer une ou plusieurs molécules d'interférence telles que l'urée d'un échantillon d'urine, où lesdites molécules d'interférence modifient la performance des dosages immunologiques à écoulement latéral (LFA). Dans un mode de réalisation, un système aqueux biphase (ATPS) entièrement incorporé dans un matériau poreux permet la séparation spontanée des phases et les pathogènes provoquant la IST cible sont concentrés dans l'une des phases séparées. Dans un mode de réalisation, un module de détection tel qu'un dispositif de dosage immunologique à écoulement latéral (LFA) est utilisé conjointement avec d'autres modules de façon à détecter ou à diagnostiquer les infections sexuellement transmissibles ou les pathogènes associés aux IST à une performance améliorée.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)