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1. WO2019046557 - DEVICES AND METHODS FOR PROCESSING FLUID SAMPLES

Publication Number WO/2019/046557
Publication Date 07.03.2019
International Application No. PCT/US2018/048809
International Filing Date 30.08.2018
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 27/447 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
C12M 1/42 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
42Apparatus for the treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic wave
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
B01J 19/08 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
08Processes employing the direct application of electric or wave energy, or particle radiation; Apparatus therefor
CPC
B01J 19/0086
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0086Processes carried out with a view to control or to change the pH-value; Applications of buffer salts; Neutralisation reactions
C12M 33/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
33Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
G01N 1/40
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation ; including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
40Concentrating samples
G01N 27/44704
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
44704Details; Accessories
G01N 27/44791
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
44756Apparatus specially adapted therefor
44791Microapparatus
G01N 33/54366
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
Applicants
  • UNIVERSITY OF CINCINNATI [US]/[US]
Inventors
  • HEIKENFELD, Jason, Charles
  • JAJACK, Andrew
  • GOMEZ, Eliot
  • BROTHERS, Michael, Charles
  • STAMPER, Isaac
Agents
  • ARDIZZONE, Timothy, D.
  • BELLAMY, Glenn, D.
  • AHRENS, Gregory, F.
  • BENINTENDI, Steven, W.
  • BIEBER, John, H.
Priority Data
62/551,82630.08.2017US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DEVICES AND METHODS FOR PROCESSING FLUID SAMPLES
(FR) DISPOSITIFS ET PROCÉDÉS DE TRAITEMENT D'ÉCHANTILLONS DE FLUIDE
Abstract
(EN)
Described are devices for and methods of modulating a fluid sample. The devices (10, 40, 60, 80, 100, 130, 160, 220) include at least one sample-modulating component (20, 76, 78, 90, 110, 112, 116, 150, 152, 154, 162, 164, 182, 184, 186, 222, and 230) and, in some embodiments, two or more sample-modulating components. The sample-modulating components are each capable of performing a function selected from the following group: concentrating the sample to increase a concentration of a first constituent of the sample; diluting the sample to decrease a concentration of a second constituent in of the sample; desalinating the sample to decrease the total moles of salt in the sample volume or causing a temporary decrease in the osmolarity; adjusting pH of the sample to bring a pH of the sample into a predetermined range; absorbing one or more nonpolar substances to decrease a concentration of the nonpolar substances; and delivering one or more reagents to the sample to provide a desired concentration of the reagent in the sample.
(FR)
L'invention concerne des dispositifs et des procédés de modulation d'un échantillon de fluide. Les dispositifs 10, 40, 60, 80, 100, 130, 160, 220 comprennent au moins un composant de modulation d'échantillon 20, 76, 78, 90, 110, 112, 116, 150, 152, 154, 162, 164, 182, 184, 186, 222, et 230 et, dans certains modes de réalisation, au moins deux composants de modulation d'échantillon. Chaque composant de modulation d'échantillon est capable de remplir une fonction choisie dans le groupe suivant : concentrer l'échantillon pour augmenter la concentration d'un premier constituant de l'échantillon; diluer l'échantillon pour réduire la concentration d'un second constituant de l'échantillon; dessaler l'échantillon pour réduire les moles totales de sel dans le volume d'échantillon ou provoquer une baisse temporaire de l'osmolarité; ajuster le pH de l'échantillon pour amener le pH de l'échantillon dans une plage prédéfinie; absorber une ou plusieurs substances non polaires pour réduire une concentration desdites substances non polaires; et distribuer un ou plusieurs réactifs dans l'échantillon pour obtenir une concentration souhaitée du réactif dans l'échantillon.
Also published as
Latest bibliographic data on file with the International Bureau