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1. (WO2019046553) METHOD AND DEVICE OF USING AQUEOUS TWO-PHASE SYSTEMS (ATPS) FOR ENHANCING DIAGNOSTICS FOR DENTAL AND ORAL DISEASES
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Pub. No.: WO/2019/046553 International Application No.: PCT/US2018/048802
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
G01N 33/53 (2006.01) ,G01N 33/536 (2006.01) ,G01N 1/34 (2006.01) ,G01N 1/40 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
536
with immune complex formed in liquid phase
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1
Sampling; Preparing specimens for investigation
28
Preparing specimens for investigation
34
Purifying; Cleaning
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1
Sampling; Preparing specimens for investigation
28
Preparing specimens for investigation
40
Concentrating samples
Applicants:
PHASE DIAGNOSTICS, INC. [US/US]; 10527 Garden Grove Blvd Garden Grove, California 92843, US
Inventors:
CHIU, Yin To; US
MOSLEY, Garrett Lee; US
LEE, Brian Sangwoo; US
Agent:
LAW OFFICES OF ALBERT WAI-KIT CHAN, PLLC; World Plaza, Suite 604 141-07 20th Avenue Whitestone, New York 11357, US
Priority Data:
62/553,20501.09.2017US
Title (EN) METHOD AND DEVICE OF USING AQUEOUS TWO-PHASE SYSTEMS (ATPS) FOR ENHANCING DIAGNOSTICS FOR DENTAL AND ORAL DISEASES
(FR) PROCÉDÉ ET DISPOSITIF D'UTILISATION DE SYSTÈMES AQUEUX À DEUX PHASES (ATPS) PERMETTANT L'AMÉLIORATION DU DIAGNOSTIC DE MALADIES DENTAIRES ET BUCCALES
Abstract:
(EN) This invention relates to a method and device to improve the detection accuracy and performance for diagnosing dental disorders or diseases by improving the sensitivity of the Lateral-Flow Immunoassay (LFA). The present method and device are related to removing the protein interference (impurities) from sample and using aqueous two-phase system (ATPS) embedded entirely within a porous material, allowing spontaneous phase separation and concentration, for detection using the Lateral-Flow Immunoassay (LFA). The present invention also provides a platform technology for screening different types of specimens with increased sensitivity, and screening antibodies for optimal detection in various types of samples.
(FR) La présente invention concerne un procédé et un dispositif permettant d'améliorer la précision et la performance de détection du diagnostic de troubles ou de maladies dentaires par l'amélioration de la sensibilité de l'immunoessai à écoulement latéral (LFA). Le procédé et le dispositif de l'invention se rapportent à l'élimination de l'interférence protéique (impuretés) de l'échantillon et à l'utilisation d'un système aqueux à deux phases (ATPS) intégré entièrement à l'intérieur d'un matériau poreux, permettant une séparation et une concentration de phase spontanées, pour permettre une détection à l'aide de l'immunoessai à écoulement latéral (LFA). La présente invention concerne également une technologie de plateforme permettant de cribler différents types d'échantillons avec une sensibilité accrue, et de cribler des anticorps pour une détection optimale dans divers types d'échantillons.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)