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1. (WO2019046534) DEUTERATED INDOLOQUINOLINE COMPOUNDS
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Pub. No.: WO/2019/046534 International Application No.: PCT/US2018/048758
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C07D 471/04 (2006.01) ,A61P 25/16 (2006.01) ,A61P 25/22 (2006.01) ,A61P 25/28 (2006.01) ,A61P 25/18 (2006.01) ,A61K 31/437 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
14
for treating abnormal movements, e.g. chorea, dyskinesia
16
Anti-Parkinson drugs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
18
Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
4353
ortho- or peri-condensed with heterocyclic ring systems
437
the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
Applicants:
REDIVIVUS PHARMACEUTICALS, LLC [US/US]; 108 Forest Avenue Hudson, MA 01749, US
Inventors:
WELLS, David, S.; US
Agent:
DAVIS, Steven, G.; US
BOWLES, Anita, M.; US
BLAZESKI, George; US
BROWN, Ronald, E.; US
BAI, Mei; US
Priority Data:
62/552,54031.08.2017US
Title (EN) DEUTERATED INDOLOQUINOLINE COMPOUNDS
(FR) COMPOSÉS D'INDOLOQUINOLINE DEUTÉRÉS
Abstract:
(EN) The invention is directed to novel quinone reductase 2 (QR2) inhibitors represented by Formula (I): and pharmaceutically acceptable salts thereof. The variables for Formula (I) are defined herein and the compound comprises at least one deuterium atom. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of preventing and/or therapeutically treating diseases and conditions that are beneficially prevented and/or treated by administering a QR2 inhibitor.
(FR) L'invention concerne de nouveaux inhibiteurs de quinone réductase 2 (QR2) représentés par la formule (I) : et des sels pharmaceutiquement acceptables de ceux-ci. Les variables de formule (I) sont définies dans la description, et le composé comprend au moins un atome de deutérium. L'invention concerne également des compositions comprenant un composé selon l'invention et l'utilisation de telles compositions dans des procédés de prévention et/ou de traitement thérapeutique de maladies et d'affections qui sont traitées et/ou pouvant être prévenues de manière avantageuse par l'administration d'un inhibiteur de QR2.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)