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1. (WO2019046497) QUINOLINE DERIVATIVE, COMPOSITIONS COMPRISING THIS COMPOUND AND USES THEREOF IN THE TREATMENT OF CANCER
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Pub. No.: WO/2019/046497 International Application No.: PCT/US2018/048660
Publication Date: 07.03.2019 International Filing Date: 30.08.2018
IPC:
C07D 215/42 (2006.01) ,A61K 31/4706 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38
Nitrogen atoms
42
attached in position 4
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4706
4-Aminoquinolines; 8-Aminoquinolines, e.g. chloroquine, primaquine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC. [US/US]; The Nucleus Building 300 East Market Street, Suite 300 Louisville, Kentucky 40202-1959, US
Inventors:
TELANG, Sucheta; US
CHESNEY, Jason; US
TRENT, John O.; US
BURLISON, Joseph A.; US
Agent:
GUTTMAN, Harry J.; US
Priority Data:
62/552,71631.08.2017US
Title (EN) QUINOLINE DERIVATIVE, COMPOSITIONS COMPRISING THIS COMPOUND AND USES THEREOF IN THE TREATMENT OF CANCER
(FR) DÉRIVÉ DE QUINOLINE, COMPOSITIONS COMPRENANT CE COMPOSÉ ET UTILISATIONS ASSOCIÉES DANS LE TRAITEMENT DU CANCER
Abstract:
(EN) Some embodiments of the invention include inventive compounds (e.g., compounds of Formula (I)). Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as cancer). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.
(FR) Certains modes de réalisation de l'invention concernent des composés selon l'invention (par exemple, des composés de Formule (I)). D'autres modes de réalisation comprennent des compositions (par exemple, des compositions pharmaceutiques) comprenant le composé selon l'invention. Encore d'autres modes de réalisation de l'invention comprennent des compositions (par exemple, des compositions pharmaceutiques) destinées au traitement, par exemple, de certaines maladies à l'aide des composés de l'invention. Certains modes de réalisation comprennent des procédés d'utilisation du composé de l'invention (par exemple, dans des compositions ou dans des compositions pharmaceutiques) pour une administration et un traitement (par exemple, des maladies telles que le cancer). D'autres modes de réalisation comprennent des procédés de production des composés de l'invention. D'autres modes de réalisation de l'invention sont également traités dans la description.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)