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1. (WO2019046491) LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS
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Pub. No.: WO/2019/046491 International Application No.: PCT/US2018/048642
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
A61K 31/015 (2006.01) ,A61K 31/495 (2006.01) ,A61K 31/4985 (2006.01) ,C07C 13/12 (2006.01) ,C07D 473/32 (2006.01) ,C07D 473/34 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
01
Hydrocarbons
015
carbocyclic
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4985
Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
13
Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
02
Monocyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
08
with a five-membered ring
12
with a cyclopentene ring
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
26
with an oxygen, sulfur, or nitrogen atom directly attached in position 2 or 6, but not in both
32
Nitrogen atom
34
attached in position 6, e.g. adenine
Applicants:
ARIYA THERAPEUTICS, INC. [US/US]; 501 Boylston Street, Suite 6102 Boston, Massachusetts 02116, US
MONASH UNIVERSITY [AU/AU]; Wellington Road Clayton, Victoria 3800, AU
Inventors:
BONNER, Daniel Kenneth; US
KARANAM, Ketki; US
MUTAMBA, James T.; US
SHYAM, Rishab R.; US
SIMPSON, Jamie; US
HAN, Sifei; AU
HU, Luojuan; AU
PORTER, Christopher John Hamilton; AU
QUACH, Tim; AU
TREVASKIS, Natalie; AU
Agent:
REID, Andrea L.C.; US
ARICO, Joseph W.; US
FLEMING, Paul R.; US
OH, Euk Charlie; US
SCALTRITO, Donald V.; US
NIHAN, Danielle M.; US
WANG, Gang; US
PRAIRIE, Nicholas; US
DAVIS, Chad E.; US
DECHERT LLP; One International Place, 40th Floor 100 Oliver Street Boston, Massachusetts 02110-2605, US
Priority Data:
62/551,62729.08.2017US
62/607,70019.12.2017US
62/607,74919.12.2017US
62/714,02902.08.2018US
62/724,27429.08.2018US
62/724,44029.08.2018US
Title (EN) LYMPHATIC SYSTEM-DIRECTING LIPID PRODRUGS
(FR) PROMÉDICAMENTS LIPIDIQUES ORIENTANT VERS LE SYSTÈME LYMPHATIQUE
Abstract:
(EN) The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
(FR) La présente invention concerne des promédicaments lipidiques orientant vers le système lymphatique, des compositions pharmaceutiques correspondantes, des procédés de production de tels promédicaments et de telles compositions, ainsi que des procédés permettant d'améliorer la biodisponibilité ou d'autres propriétés d'un agent thérapeutique qui comprend une partie du promédicament lipidique. La présente invention concerne également des méthodes de traitement de maladies, troubles ou états pathologiques tels que ceux décrits dans la description, comprenant l'administration au patient nécessitant un tel traitement d'un promédicament lipidique de l'invention ou d'une composition pharmaceutique correspondante.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)