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1. (WO2019046483) SYSTEMS, METHODS, AND STRUCTURES FOR SURFACE ACOUSTIC WAVE-BASED SEPARATION
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Pub. No.: WO/2019/046483 International Application No.: PCT/US2018/048629
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
B01D 43/00 (2006.01) ,B01D 21/28 (2006.01) ,B06B 1/00 (2006.01) ,C12N 13/00 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
43
Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
D
SEPARATION
21
Separation of suspended solid particles from liquids by sedimentation
28
Mechanical auxiliary equipment for acceleration of sedimentation, e.g. by vibrators or the like
B PERFORMING OPERATIONS; TRANSPORTING
06
GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
B
GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
1
Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
13
Treatment of micro-organisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
Applicants:
DUKE UNIVERSITY [US/US]; 2812 Erwin Road Suite 306 Durham, NC 27705, US
Inventors:
HUANG, Jun; US
WU, Mengxi; US
Agent:
BROSEMER, Jeffery, J.; US
Priority Data:
62/551,27029.08.2017US
Title (EN) SYSTEMS, METHODS, AND STRUCTURES FOR SURFACE ACOUSTIC WAVE-BASED SEPARATION
(FR) SYSTÈMES, PROCÉDÉS ET STRUCTURES DE SÉPARATION BASÉE SUR DES ONDES ACOUSTIQUES DE SURFACE
Abstract:
(EN) Aspects of the present disclosure describe systems, methods, and structures for acoustic wave-based separation of particulates in a fluidic flow. Illustrative systems, methods, and structures according to aspects of the present disclosure may advantageously provide for the continuous, label-free, non-invasive separation of the particulates that include - among other types - difficult-to-separate biological particulates and in particular those in blood including circulating tumor cells and micro-blood-borne particles and other subgroups of extracellular vesicles including nanoscale exosomes.
(FR) Des aspects de la présente invention concernent des systèmes, des procédés et des structures pour la séparation basée sur des ondes acoustiques de particules dans un écoulement fluidique. Les systèmes, des procédés et des structures décrits selon des aspects de la présente invention peuvent avantageusement permettre la séparation non invasive, en continu et sans marqueur des particules incluant, entre autres, des particules biologiques difficiles à séparer et en particulier celles contenues dans le sang y compris les cellules tumorales circulantes et les microparticules en suspension dans le sang, et d'autres sous-groupes de vésicules extracellulaires comprenant des exosomes à l'échelle nanométrique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)