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1. (WO2019046467) THERAPEUTIC INDAZOLES
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Pub. No.: WO/2019/046467 International Application No.: PCT/US2018/048611
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
C07D 231/56 (2006.01) ,A61K 31/416 (2006.01) ,A61P 31/06 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54
condensed with carbocyclic rings or ring systems
56
Benzopyrazoles; Hydrogenated benzopyrazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415
1,2-Diazoles
416
condensed with carbocyclic ring systems, e.g. indazole
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04
Antibacterial agents
06
for tuberculosis
Applicants:
FREUNDLICH, Joel S. [US/US]; US
ALLAND, David [US/US]; US
NEIDITCH, Matthew B. [US/US]; US
KUMAR, Pradeep [US/US]; US
CAPODAGLI, Glenn [US/US]; US
AWASTHI, Divya [US/US]; US
EKINS, Sean [US/US]; US
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US/US]; Old Queens, Somerset and George Streets New Brunswick, New Jersey 08901, US
Inventors:
FREUNDLICH, Joel S.; US
ALLAND, David; US
NEIDITCH, Matthew B.; US
KUMAR, Pradeep; US
CAPODAGLI, Glenn; US
AWASTHI, Divya; US
EKINS, Sean; US
Agent:
HARRIS, Robert J.; US
VIKSNINS, Ann S.; US
MALEN, Peter L.; US
MICKELSON, John W.; US
KRUEGER, Katherine A.D.; US
KLIMA SILBERG, Catherine I.; US
PADYS, Danny J.; US
ANDRUS, Alex; US
Priority Data:
62/551,53429.08.2017US
Title (EN) THERAPEUTIC INDAZOLES
(FR) INDAZOLES THÉRAPEUTIQUES
Abstract:
(EN) The invention provides compounds of formula (I): and salts thereof wherein R1-R5 have any of the meanings described in the specification. The compounds are useful for treating bacterial infections (e.g. tuberculosis).
(FR) La présente invention concerne des composés de formule (I): et des sels de ceux-ci, dans la formule, R1-R5 ont l'une quelconque des valeurs définies dans la description. Ces composés sont utiles dans le traitement d'infections bactériennes (par exemple, la tuberculose).
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)