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1. (WO2019046455) MICROFLUIDIC TISSUE BIOPSY AND IMMUNE RESPONSE DRUG EVALUATION DEVICES AND SYSTEMS
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Pub. No.: WO/2019/046455 International Application No.: PCT/US2018/048592
Publication Date: 07.03.2019 International Filing Date: 29.08.2018
IPC:
B01L 3/00 (2006.01) ,G01N 33/50 (2006.01)
B PERFORMING OPERATIONS; TRANSPORTING
01
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
L
CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3
Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
THE CHARLES STARK DRAPER LABORATORY INC. [US/US]; 555 Technology Square Cambridge, Massachusetts 02139, US
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Avenue Cambridge, Massachusetts 02139, US
Inventors:
BECKWITH, Ashley Lynne; US
BORENSTEIN, Jeffrey; US
MOORE, Nathan; US
DOTY, Daniel; US
VELASQUEZ-GARCIA, Luis; US
Agent:
McKENNA, Christopher J.; US
HUNTER, Paul; US
Priority Data:
62/552,26430.08.2017US
62/581,66704.11.2017US
Title (EN) MICROFLUIDIC TISSUE BIOPSY AND IMMUNE RESPONSE DRUG EVALUATION DEVICES AND SYSTEMS
(FR) DISPOSITIFS ET SYSTÈMES MICROFLUIDIQUES DE BIOPSIE DE TISSUS ET D'ÉVALUATION DE MÉDICAMENT INDUISANT UNE RÉPONSE IMMUNITAIRE
Abstract:
(EN) This disclosure describes microfluidic tissue biopsy and immune response drug evaluation devices and systems. A microfluidic device can include an inlet channel having a first end configured to receive a fluid sample optionally containing a tissue sample. The microfluidic device can also include a tissue trapping region at the second end of the inlet channel downstream from the first end. The tissue trapping region can include one or more tissue traps configured to catch a tissue sample flowing through the inlet channel such that the fluid sample contacts the tissue trap. The microfluidic device can also include one or more channels providing an outlet.
(FR) La présente invention concerne des dispositifs et des systèmes microfluidiques de biopsie de tissus et d'évaluation de médicament induisant une réponse immunitaire. Un dispositif microfluidique peut comprendre un canal d'entrée ayant une première extrémité conçue pour recevoir un échantillon de fluide contenant éventuellement un échantillon de tissu. Le dispositif microfluidique peut également comprendre une région de piégeage de tissu au niveau de la seconde extrémité du canal d'entrée en aval de la première extrémité. La région de piégeage de tissu peut comprendre un ou plusieurs pièges à tissu conçus pour attraper un échantillon de tissu s'écoulant à travers le canal d'entrée de sorte que l'échantillon de fluide entre en contact avec le piège à tissu. Le dispositif microfluidique peut également comprendre un ou plusieurs canaux fournissant une sortie.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)